FIGURE

Fig. 3

ID

ZDB-FIG-070918-53

Publication

Walker et al., 2006 - Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning

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Fig. 3

Both FurinA and FurinB function are required to activate Edn1 signaling. Flat mounts of Alcian-stained cartilages and bones at 5–6 dpf. (A) Wild-type, (B) furinA mutant, (C) furinA MO-injected larva, (D) furinB MO-injected larva, (E) furinB MO injected into furinA mutant, (F) low edn1 MO-injected larva, (G) edn1 mutant, and (H) dlx3b MO + dlx5a MO-injected larva. Wild-type DV joint regions are indicated with arrows in panel A. Fusions at joint regions are indicated with asterisks in panels B–H. Scale bar: 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	edn1^{tf216b/tf216b} furina^{unspecified/unspecified} WT + MO1-edn1 WT + MO1-furina WT + MO1-furinb furina^tg419/tg419 + MO1-furinb WT + MO1-dlx3b + MO1-dlx5a (all 7)
Knockdown Reagents:	MO1-dlx3b MO1-dlx5a MO1-edn1 MO1-furina MO1-furinb
Observed In:	ceratohyal cartilage interhyal-epihyal joint mandibular arch skeleton joint Meckel's cartilage palatoquadrate cartilage pharyngeal arch 3 skeleton pharyngeal arch 4 skeleton (all 7)
Stage:	Day 5

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 295(1), Walker, M.B., Miller, C.T., Talbot, J.C., Stock, D.W., and Kimmel, C.B., Zebrafish furin mutants reveal intricacies in regulating Endothelin1 signaling in craniofacial patterning, 194-205, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.