FIGURE

Fig. 1

ID

ZDB-FIG-070918-42

Publication

Ho et al., 2006 - Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo

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Fig. 1

SB-431542 reversibly blocks phospho-Smad2 in Xenopus animal cap explants and zebrafish embryos. Western blots for p-Smad2 were performed on (A) Xenopus animal caps treated with 100 μM SB-431542 or DMSO followed by 0.3 nM soluble activin protein, (B) 50% epiboly zebrafish embryos treated with 100 μM SB-431542 or DMSO at 16-cell stage, and (C) tails from stage 34 embryos treated with 100 μM SB-431542 or DMSO at stage 19 for 24 h and either washed (lane 1) or unwashed (lanes 2 and 3) for 16 h. Cytoskeletal actin was used as a loading control.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 295(2), Ho, D.M., Chan, J., Bayliss, P., and Whitman, M., Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo, 730-742, Copyright (2006) with permission from Elsevier. Full text @ Dev. Biol.