FIGURE

Fig. 7

ID

ZDB-FIG-070914-47

Publication

McCollum et al., 2007 - A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3

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Fig. 7

Overexpression of lmo4b reduces telencephalon and eye size. Embryos in the left were injected with 750 pg gfp mRNA, and embryos on the right were injected with 750 pg lmo4b mRNA. Probes and stages indicated on the far left. (A, B) Lateral views of 3 dpf larvae. Panels C–H, K, L are dorsal views of the anterior region. In panels E–H, emx1 staining is blue and pax6b staining is orange. Panels I, J are lateral views of the anterior region. Panels M, N are ventral views. zli-zona limitans intrathalamica; h = hypothalamus. t = telencephalon.

Expression Data

Genes:	dlx3b emx1 nkx2.4b pax2a pax6b rx2 shha (all 7)
Fish:	WT WT + MO2-lmo4a + MO3-lmo4a
Knockdown Reagents:	MO2-lmo4a MO3-lmo4a
Anatomical Terms:	hypothalamus neural plate optic vesicle presumptive telencephalon unspecified
Stage Range:	1-4 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 309(2), McCollum, C.W., Amin, S.R., Pauerstein, P., and Lane, M.E., A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3, 373-385, Copyright (2007) with permission from Elsevier. Full text @ Dev. Biol.