Gene
rx2
- ID
- ZDB-GENE-990415-237
- Name
- retinal homeobox gene 2
- Symbol
- rx2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within camera-type eye photoreceptor cell differentiation. Predicted to be located in nucleus. Is expressed in eye; immature eye; optic primordium; and presumptive diencephalon. Human ortholog(s) of this gene implicated in age related macular degeneration 6; cone-rod dystrophy 11; isolated microphthalmia 3; and retinitis pigmentosa 95. Orthologous to human RAX (retina and anterior neural fold homeobox) and RAX2 (retina and anterior neural fold homeobox 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 25 figures from 24 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Nelson et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa31303 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-rx2 | N/A | Rojas-Munoz et al., 2005 |
| MO2-rx2 | N/A | (2) |
| MO3-rx2 | N/A | Nelson et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| isolated microphthalmia 3 | Alliance | Microphthalmia, syndromic 16 | 611038 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | OAR domain | Retinal homeobox protein RAX/RAX2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:O42357 | InterPro | 327 | |||||
| UniProtKB:F1QNV0 | InterPro | 327 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(rx2:d2EGFP) |
|
| 1 | Tang et al., 2017 | |
| Tg(rx2:GAL4) |
|
| 1 | (2) | |
| Tg(rx2:GAL4,myl7:EGFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-332L5 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131226 (1) | 1489 nt | ||
| Genomic | GenBank:CU855756 (2) | 106307 nt | ||
| Polypeptide | UniProtKB:F1QNV0 (1) | 327 aa |
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Letelier, J., Buono, L., Almuedo-Castillo, M., Zang, J., Mounieres, C., González-Díaz, S., Polvillo, R., Sanabria-Reinoso, E., Corbacho, J., Sousa-Ortega, A., Diez Del Corral, R., Neuhauss, S.C.F., Martínez-Morales, J.R. (2023) Mutation of vsx genes in zebrafish highlights the robustness of the retinal specification network. eLIFE. 12:
- Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)
- Vigouroux, R.J., Duroure, K., Vougny, J., Albadri, S., Kozulin, P., Herrera, E., Nguyen-Ba-Charvet, K., Braasch, I., Suárez, R., Del Bene, F., Chédotal, A. (2021) Bilateral visual projections exist in non-teleost bony fish and predate the emergence of tetrapods. Science (New York, N.Y.). 372:150-156
- Sundaramurthi, H., Roche, S.L., Grice, G.L., Moran, A., Dillion, E.T., Campiani, G., Nathan, J.A., Kennedy, B.N. (2020) Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness. Frontiers in cell and developmental biology. 8:689
- Zhao, G., Sun, H., Zhang, T., Liu, J.X. (2020) Copper induce zebrafish retinal developmental defects via triggering stresses and apoptosis. Cell communication and signaling : CCS. 18:45
- Albadri, S., Naso, F., Thauvin, M., Gauron, C., Parolin, C., Duroure, K., Vougny, J., Fiori, J., Boga, C., Vriz, S., Calonghi, N., Del Bene, F. (2019) Redox Signaling via Lipid Peroxidation Regulates Retinal Progenitor Cell Differentiation. Developmental Cell. 50(1):73-89.e6
- Breuer, M., Guglielmi, L., Zielonka, M., Hemberger, V., Kölker, S., Okun, J.G., Hoffmann, G.F., Carl, M., Sauer, S.W., Opladen, T. (2019) QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. PLoS One. 14:e0215162
- Umali, J., Hawkey-Noble, A., French, C.R. (2019) Loss of foxc1 in zebrafish reduces optic nerve size and cell number in the ganglion cell layer. Vision Research. 156:66-72
- Zhang, Y., Wang, Z., Zhao, G., Liu, J.X. (2018) Silver nanoparticles affect lens rather than retina development in zebrafish embryos. Ecotoxicology and environmental safety. 163:279-288
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