Gene
emx1
- ID
- ZDB-GENE-031007-7
- Name
- empty spiracles homeobox 1
- Symbol
- emx1 Nomenclature History
- Previous Names
-
- zgc:101821
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within pronephric distal tubule development. Predicted to be active in nucleus. Is expressed in several structures, including forebrain; forebrain neural keel; neural plate; presumptive telencephalon; and pronephros. Orthologous to human EMX1 (empty spiracles homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 69 figures from 52 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-emx1 | N/A | (2) |
| MO2-emx1 | N/A | Viktorin et al., 2009 |
| MO3-emx1 | N/A | Morales et al., 2018 |
| MO4-emx1 | N/A | Morales et al., 2018 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | EMX/VAX/Noto Homeobox Transcription Factors | Helix-turn-helix motif | Homedomain-like superfamily | Homeobox, conserved site | Homeodomain | Homeodomain, metazoa |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A3KNV6 | InterPro | 231 | ||||||
| UniProtKB:Q804S6 | InterPro | 231 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-159C24 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101821 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:162568 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_198144 (1) | 1251 nt | ||
| Genomic | GenBank:BX571943 (1) | 102576 nt | ||
| Polypeptide | UniProtKB:A3KNV6 (1) | 231 aa |
- Kawahara, A., Yasojima, S., Koiwa, J., Fujimaki, S., Ito, H., Yamada, M., Kosaki, K., Nishimura, Y. (2025) Establishment and characterization of adap1-deficient zebrafish. Development, growth & differentiation. :
- Le, Y., Rajasekhar, K., Loo, T.Y.J., Saunders, T.E., Wohland, T., Winkler, C. (2025) Midkine-a interacts with Ptprz1b to regulate neural plate convergence and midline formation in the developing zebrafish hindbrain. Developmental Biology. :
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Miyake, A., Ohmori, T., Murakawa, Y. (2023) Fgf22 and Fgfr2b are required for neurogenesis and gliogenesis in the zebrafish forebrain. Biochemical and Biophysical Research Communications. 681:212217212-217
- Nam, M.K., Moon, J.M., Kim, G.Y., Min Kim, S., Rhim, H. (2022) The Novel Human HtrA2 Ortholog in Zebrafish: New Molecular Insight and Challenges into the Imbalance of Homeostasis. Gene. 819:146263
- Choe, S., Huh, T.L., Rhee, M. (2020) Trim45 is essential to the development of the diencephalon and eye in zebrafish embryos. Animal cells and systems. 24:99-106
- He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
- Ando, H., Sato, T., Ito, T., Yamamoto, J., Sakamoto, S., Nitta, N., Asatsuma-Okumura, T., Shimizu, N., Mizushima, R., Aoki, I., Imai, T., Yamaguchi, Y., Berk, A.J., Handa, H. (2019) Cereblon Control of Zebrafish Brain Size by Regulation of Neural Stem Cell Proliferation. iScience. 15:95-108
- Kamei, H., Yoneyama, Y., Hakuno, F., Sawada, R., Shimizu, T., Duan, C., Takahashi, S.I. (2018) Catch-up growth in zebrafish embryo requires neural crest cells sustained by Irs1-signaling. Endocrinology. 159(4):1547-1560
- Morales, E.E., Handa, N., Drummond, B.E., Chambers, J.M., Marra, A.N., Addiego, A., Wingert, R.A. (2018) Homeogene emx1 is required for nephron distal segment development in zebrafish. Scientific Reports. 8:18038
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