FIGURE

Fig. 6

ID

ZDB-FIG-070813-22

Publication

Wendl et al., 2007 - Early developmental specification of the thyroid gland depends on han-expressing surrounding tissue and on FGF signals

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Fig. 6

FGF signalling is required for thyroid development. Labelling is as in Fig. 1. Anterior is to the left. Lateral (A-F,I-L) and ventral (G,H) views are shown. (A-F) Expression of thyroid markers in ace mutants and in wild-type (wt) siblings. (G,H) ace larvae have a strong reduction in thyroid gland size. (I,K) In DMSO-treated control embryos, the thyroid appears normal. (J,L,M) Following different stages of su5402 treatment, the thyroid is completely lost. (J,L) Example embryos without thyroid; (M) the complete data set. Blue bars, embryos with thyroidal nk2.1a expression; red bars, slc5a5 expression. Arrows point to the thyroid primordium; the asterisk indicates the absent midbrain-hindbrain boundary (MHB) in ace mutants.hy, hypothalamus; mhb, midbrain-hindbrain boundary, ss somite stage.

Expression Data

Genes:	hhex nkx2.4b pax2a slc5a5
Fish:	WT fgf8a^{ti282a/ti282a}
Condition:	chemical treatment: SU5402
Anatomical Terms:	hypothalamus midbrain hindbrain boundary pharyngeal endoderm thyroid follicle thyroid primordium
Stage Range:	Prim-5 to Pec-fin

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fgf8a^{ti282a/ti282a}
Observed In:	thyroid primordium
Stage Range:	Prim-5 to Prim-15

Phenotype Detail

Acknowledgments

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