ZFIN Fish: fgf8a^ti282a/ti282a

ZFIN ID: ZDB-FISH-150901-16069

ZFIN ID: ZDB-FISH-150901-16069

Fish name:	fgf8a^{ti282a/ti282a}
Genotype:	fgf8a^{ti282a/ti282a}
Targeting Reagent:	none

HUMAN DISEASE MODELED by fgf8a^{ti282a/ti282a}
No data available

GENE EXPRESSION
Gene expression in fgf8a^{ti282a/ti282a}

RNA expression

Expressed Gene	Structure	Conditions	Figures
ackr3b	diencephalon dorsal region	control	Fig. 6 from Roberson et al., 2017
aldh1a2	somite	standard conditions	Fig. 11 from Hamade et al., 2006
aldh1a3	(not) otic vesicle	standard conditions	Fig. 9 from Maier et al., 2014
aldocb	(not) cerebellum Purkinje cell	control	Fig. 3 from Jászai et al., 2003
ascl1a	optic tectum ventricular zone	standard conditions	Fig. 8 from Brand et al., 1996
ascl1b	diencephalon hindbrain	control	Fig. 4 from Jászai et al., 2003
atoh1a	(not) cerebellum macula (not) midbrain hindbrain boundary	standard conditions	Fig. 3 from Maier et al., 2014 Fig. 4 from Foucher et al., 2006 Fig. 3 from Jászai et al., 2003
barx1	pharyngeal arch 2 pharyngeal arch 3-7	standard conditions	Fig. 8 from Sperber et al., 2008
calb2b	lip epithelium taste bud oral epithelium taste bud pharyngeal arch taste bud	control	Fig. 2 from Kapsimali et al., 2011
cldna	otic vesicle	standard conditions	Fig. 2 from Kwon et al., 2009
cnpy1	(not) midbrain hindbrain boundary	standard conditions	Fig. 1 from Hirate et al., 2006
cntn2	(not) cerebellum granule cell diencephalon hindbrain midbrain	control	Fig. 3 from Jászai et al., 2003
col2a1a	chondrocyte	control	Fig. 5 from McCarthy et al., 2016
cxcl12b	diencephalon dorsal region	control	Fig. 6 from Roberson et al., 2017
cyp26a1	tail bud	standard conditions	Fig. 11 from Hamade et al., 2006
dbx1b	diencephalon dorsal region	control	Fig. 5 from Roberson et al., 2017
dlx2a	mandibular arch skeleton mesenchyme derived from head neural crest pharyngeal arch 2 skeleton pharyngeal arch 3-7 skeleton unspecified	standard conditions	Fig. 2 from Albertson et al., 2005 Fig. 6 from Crump et al., 2004 text only from Shanmugalingam et al., 2000
dlx3b	otic placode	standard conditions	Fig. 4 from Mackereth et al., 2005
dmbx1a	midbrain neural rod	control	Fig. 2 from Jászai et al., 2003
dusp6	unspecified	standard conditions	text only from Tsang et al., 2004
efna5a	eye optic cup anterior region presumptive neural retina	standard conditions	Fig. 11 from McMahon et al., 2009 Fig. 1 from Picker et al., 2009 Fig. 3 from Picker et al., 2005
egr2b	rhombomere 3 rhombomere 5 unspecified	standard conditions	Fig. 6 from Crump et al., 2004 text only from Wiellette et al., 2004
emx3	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
en1a	pectoral fin bud antero-ventral region	standard conditions	Fig. 11 from Reifers et al., 1998
en2a	constrictor dorsalis (not) midbrain hindbrain boundary midbrain hindbrain boundary neural keel muscle pioneer	standard conditions	Fig. 2 from Knight et al., 2008 Fig. 8 , Fig. 10 from Reifers et al., 1998
epha4a	diencephalon forebrain midbrain boundary rhombomere 1 rhombomere 3 rhombomere 5 unspecified	standard conditions	text only from Teraoka et al., 2004 Fig. 4 from Jászai et al., 2003 text only from Durbin et al., 2000
epha4b	eye optic cup posterior region presumptive neural retina	standard conditions	Fig. 11 from McMahon et al., 2009 Fig. 1 from Picker et al., 2009 Fig. 3 from Picker et al., 2005
etv4	(not) midbrain hindbrain boundary (not) midbrain hindbrain boundary neural plate	standard conditions	Fig. S2 from Foucher et al., 2006
etv5b	(not) midbrain hindbrain boundary (not) midbrain hindbrain boundary neural plate unspecified	standard conditions	Fig. 6 from Foucher et al., 2006 text only from Scholpp et al., 2004
eya1	unspecified	standard conditions	Fig. 5 from Nechiporuk et al., 2007
fgf3	(not) midbrain hindbrain boundary neural rod	standard conditions	Fig. S1 from Foucher et al., 2006
fgf8a	fin fold pectoral fin bud midbrain hindbrain boundary neural keel (not) whole organism	standard conditions	Fig. 6, Fig. 7 from Guo et al., 1999 Fig. 5, Fig. 11 from Reifers et al., 1998
fgfr3	unspecified	standard conditions	text only from Tallafuss et al., 2003
foxa2	endoderm	standard conditions	Fig. 6 from Crump et al., 2004
foxd5	adaxial cell (not) segmental plate anterior region	standard conditions	Fig. 5 from Lee et al., 2009
foxg1a	presumptive neural retina	standard conditions	Fig. 3 from Picker et al., 2005
foxi1	neurogenic placode	standard conditions	Fig. 5 from Nechiporuk et al., 2007
gap43	(not) cerebellum granule cell diencephalon hindbrain midbrain	control	Fig. 3 from Jászai et al., 2003
gata4	anterior lateral plate mesoderm	standard conditions	Fig. 3 from Reifers et al., 2000
gata6	anterior lateral plate mesoderm	standard conditions	Fig. 3 from Reifers et al., 2000
gbx2	(not) hindbrain neural keel (not) unspecified	standard conditions	Fig. 7 from Foucher et al., 2006 text only from Reim et al., 2002
gnrh2	midbrain	standard conditions	Fig. 3 from Whitlock et al., 2005
grem1a	(not) segmental plate somite	standard conditions	Fig. 7 from Nicoli et al., 2005
has2	mesoderm anterior region	control	Fig. 7 , Fig. 8 from McCarthy et al., 2016
	(not) mesoderm anterior region	chemical treatment: SU5402	Fig. 8 from McCarthy et al., 2016
her5	(not) midbrain hindbrain boundary midbrain hindbrain boundary neural keel unspecified	standard conditions	text only from Tallafuss et al., 2003 Fig. 8 from Reifers et al., 1998
her11	midbrain hindbrain boundary	standard conditions	Fig. 3 from Ninkovic et al., 2005
hesx1	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
hhex	pharyngeal endoderm	standard conditions	Fig. 6 from Wendl et al., 2007
hmx3a	anterior lateral line placode otic vesicle posterior lateral line placode (not) statoacoustic (VIII) ganglion	standard conditions	Fig. 3 from Adamska et al., 2000
ier2a	notochord tail bud	standard conditions	Fig. S3 from Hong et al., 2009
irx1b	diencephalon hindbrain midbrain rhombomere 1	standard conditions	Fig. S3 from Foucher et al., 2006
irx2a	diencephalon hindbrain midbrain rhombomere 1	standard conditions	Fig. S3 from Foucher et al., 2006
kdrl	(not) midbrain hindbrain boundary blood vessel	standard conditions	Fig. 1 from Reifers et al., 2000
lhx1a	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
lhx1b	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
lmo4a	unspecified	standard conditions	Fig. 4 from Lane et al., 2002
ltbp3	presumptive bulbus arteriosus	standard conditions	Fig. S1 from Zeng et al., 2014
mafba	unspecified	standard conditions	text only from Wiellette et al., 2004
mdkb	(not) cerebellum diencephalon hindbrain spinal cord	standard conditions	Fig. 6 from Winkler et al., 2001
mef2cb	(not) presumptive bulbus arteriosus	standard conditions	Fig. S1 from Zeng et al., 2014
mespaa	segmental plate anterior region	standard conditions	Fig. 7 from Lee et al., 2009
mespba	segmental plate anterior region	standard conditions	Fig. 7 from Lee et al., 2009
myf5	somite tail bud	standard conditions	Fig. 3 from Groves et al., 2005
myh6	heart rudiment	standard conditions	Fig. 2 from Marques et al., 2008
myh7	heart rudiment	standard conditions	Fig. 2 from Marques et al., 2008
myhz1.1	unspecified	standard conditions	text only from Mathieu et al., 2004
myl7	heart primordium	standard conditions	Fig. S2 from Keegan et al., 2005
mylpfa	somite	standard conditions	Fig. 2 from Groves et al., 2005
myod1	adaxial cell intermediate mesoderm mesoderm medial region (not) otic placode paraxial mesoderm segmental plate somite unspecified	standard conditions	Fig. 5 from Kok et al., 2010 Fig. 5 from Ochi et al., 2008 Fig. 5 from Plaster et al., 2007 Fig. 10 , Fig. 11 from Hamade et al., 2006 Fig. 3 from Groves et al., 2005 text only from Mathieu et al., 2004 Fig. 10 from Reifers et al., 1998
	adaxial cell somite	chemical treatment by environment: 4-(diethylamino)benzaldehyde	Fig. 10 from Hamade et al., 2006
neurod1	(not) cerebellum granule cell	control	Fig. 3 from Jászai et al., 2003
neurog1	anterior lateral line ganglion facial ganglion glossopharyngeal ganglion statoacoustic (VIII) ganglion vagal ganglion 1 vagal ganglion 2 vagal ganglion 4	standard conditions	Fig. 5 from Nechiporuk et al., 2007
nkx2.1	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
nkx2.3	pharyngeal pouches 2-6	standard conditions	Fig. 2 from Albertson et al., 2005
nkx2.4b	hypothalamus pharyngeal endoderm	standard conditions	Fig. 6 from Wendl et al., 2007
nkx2.5	heart primordium heart tube	standard conditions	Fig. 3 from Reifers et al., 2000
nkx2.7	endoderm lateral plate mesoderm	standard conditions	Fig. 6 from Crump et al., 2004 Fig. 3 from Reifers et al., 2000
noto	fast muscle cell	standard conditions	Fig. 3 from Mann et al., 2007
ntn1b	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
otpb	caudal tuberculum preoptic area supraoptic commissure	standard conditions	Fig. 7 , Fig. 9 from Del Giacco et al., 2006
otx2b	hindbrain neural keel midbrain midbrain neural rod unspecified	standard conditions	Fig. 7 from Foucher et al., 2006 Fig. 2 , Fig. 4 from Jászai et al., 2003 text only from Tallafuss et al., 2003
pax2a	ectoderm epibranchial field glossopharyngeal placode hindbrain anterior region intermediate mesoderm (not) midbrain posterior region midbrain hindbrain boundary midbrain hindbrain boundary neural keel midbrain hindbrain boundary neural rod optic cup optic stalk optic vesicle otic placode otic vesicle thyroid primordium unspecified vagal ganglion 1 vagal ganglion 2 vagal ganglion 3 vagal ganglion 4	standard conditions	14 figures from 12 publications
pax3a	nervous system somite	standard conditions	Fig. 5 from Hammond et al., 2007
pax6a	(not) cerebellum unspecified	standard conditions	Fig. 5 from Foucher et al., 2006 text only from Tallafuss et al., 2003
pax7a	somite	standard conditions	Fig. 5 from Hammond et al., 2007
pax8	(not) midbrain hindbrain boundary midbrain hindbrain boundary neural rod otic placode	standard conditions	Fig. 2 from Kwon et al., 2009 Fig. 5 from Hans et al., 2007 Fig. 4 from Mackereth et al., 2005 Fig. 1 from Jászai et al., 2003
	(not) otic placode	chemical treatment by environment: 4-(diethylamino)benzaldehyde	Fig. 5 from Hans et al., 2007
pcdh8	paraxial mesoderm segmental plate	standard conditions	Fig. 5 , Fig. 8 from Plaster et al., 2007
	paraxial mesoderm	chemical treatment: trichostatin A	Fig. 8 from Plaster et al., 2007
phox2a	hindbrain neural rod ventral region (not) locus coeruleus oculomotor nucleus trochlear motor nucleus	standard conditions	Fig. 6 from Guo et al., 1999
phox2bb	facial ganglion glossopharyngeal ganglion vagal ganglion 1 vagal ganglion 2 vagal ganglion 3 vagal ganglion 4	standard conditions	Fig. 5 from Nechiporuk et al., 2007
pitx2	floor plate diencephalic region	standard conditions	Fig. 1 from Albertson et al., 2005
reln	(not) cerebellum	standard conditions	Fig. 5 from Foucher et al., 2006
sall1a	(not) midbrain hindbrain boundary neural rod	control	Fig. 1 from Jászai et al., 2003
sema3d	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
shha	pectoral fin bud posterior margin unspecified	standard conditions	text only from Shanmugalingam et al., 2000 Fig. 11 from Reifers et al., 1998
shhb	floor plate midbrain unspecified	standard conditions	Fig. 4 from Jászai et al., 2003 text only from Shanmugalingam et al., 2000
six3a	unspecified	standard conditions	text only from Shanmugalingam et al., 2000
smarcd3b	mesoderm	standard conditions	Fig. 3 from Ochi et al., 2008
snai1a	somite tail bud	standard conditions	Fig. 10 from Reifers et al., 1998
sox2	macula	standard conditions	Fig. 3 from Maier et al., 2014
sox3	central nervous system epibranchial field neurogenic placode	standard conditions	Fig. 2 from Nikaido et al., 2007 Fig. 5 from Sun et al., 2007
sox9a	chondroblast	control	Fig. 5 from McCarthy et al., 2016
spaw	lateral plate mesoderm	standard conditions	Fig. 1 from Albertson et al., 2005
spry1	(not) diencephalon (not) midbrain hindbrain boundary (not) optic stalk (not) rhombomere tail bud	standard conditions	Fig. 6 from Komisarczuk et al., 2008
spry2	unspecified	standard conditions	Fig. 3 from Ochi et al., 2008
spry4	(not) midbrain hindbrain boundary (not) midbrain hindbrain boundary neural plate (not) midbrain hindbrain boundary neural rod optic vesicle presumptive diencephalon presumptive telencephalon	standard conditions	Fig. S2 from Foucher et al., 2006 Fig. 5 from Picker et al., 2005 Fig. 1 from Jászai et al., 2003
stm	otic vesicle	control	Fig. 5 from Hans et al., 2007
	(not) otic vesicle	chemical treatment by environment: 4-(diethylamino)benzaldehyde	Fig. 5 from Hans et al., 2007
tbx5a	eye dorsal region presumptive neural retina	standard conditions	Fig. 11 from McMahon et al., 2009 Fig. 3 from Picker et al., 2005
tbxta	axial mesoderm (not) forerunner cell group margin	standard conditions	Fig. 5 from Plaster et al., 2007 Fig. 1 from Albertson et al., 2005
tecta	macula	standard conditions	Fig. 3 from Maier et al., 2014
th	hypothalamus dopaminergic neuron (not) locus coeruleus (not) pharyngeal arch norepinephrine secreting cell unspecified	standard conditions	text only from Holzschuh et al., 2003 Fig. 4 from Jászai et al., 2003 Fig. 6 from Guo et al., 1999
tph2	unspecified	standard conditions	text only from Teraoka et al., 2004
uncx	somite	standard conditions	Fig. 8 from Nittoli et al., 2019
uncx4.1	somite	standard conditions	Fig. 8 from Nittoli et al., 2019
vax2	presumptive neural retina	standard conditions	Fig. 3 from Picker et al., 2005
wls	diencephalon	control	Fig. 6 from Roberson et al., 2017
wnt1	(not) optic tectum posterior region unspecified	standard conditions	text only from Tallafuss et al., 2003 Fig. 8 from Brand et al., 1996
wnt4	alar plate midbrain region forebrain forebrain neural rod midbrain neural rod	control	Fig. 2 from Jászai et al., 2003

Protein expression

Antibody	Antigen Genes	Structure	Conditions	Figures
Ab-MF20		atrium (not) cardiac ventricle heart tube	standard conditions	Fig. S1 from Zeng et al., 2014 Fig. 1 from Reifers et al., 2000
zn-8		cranial ganglion pharyngeal pouch	standard conditions	Fig. 4 from Choe et al., 2014
Ab2-mapk		segmental plate	standard conditions	Fig. S1 from Akiyama et al., 2014
Ab-S46		(not) cardiac ventricle	standard conditions	Fig. 1 from Reifers et al., 2000
Ab1-aldoc	aldocb	(not) cerebellum Purkinje cell	control	Fig. 3 from Jászai et al., 2003
Ab1-calb2	calb2b	lip epithelium taste bud oral epithelium taste bud pharyngeal arch taste bud	control	Fig. 2 from Kapsimali et al., 2011
Ab1-eng	en2a	(not) cerebellum constrictor dorsalis (not) optic tectum (not) tegmentum	standard conditions	Fig. 2 from Knight et al., 2008 Fig. 8 from Brand et al., 1996

Reporter gene expression No data available

PHENOTYPE
Phenotype in fgf8a^{ti282a/ti282a}

Phenotype	Conditions	Figures
alar plate midbrain region morphology, abnormal	control	Fig. 2 from Jászai et al., 2003
anatomical system quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
anterior cardinal vein absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
apoptotic process increased occurrence, abnormal	standard conditions	Fig. 5 from Jászai et al., 2003
apoptotic process occurrence, normal	standard conditions	Fig. 5 from Jászai et al., 2003
blood circulation decreased functionality, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
blood circulation disrupted, abnormal	standard conditions	Fig. 1 from Brand et al., 1996
blood vessel organization quality, normal	standard conditions	Fig. 1 from Reifers et al., 2000
blood vessel development process quality, normal	standard conditions	Fig. 1 from Reifers et al., 2000
blood vessel endothelial cell present, normal	standard conditions	Fig. 1 from Reifers et al., 2000
brain quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
brain vasculature dorsal region absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
cardiac ventricle decreased length, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
cardiac ventricle hypotrophic, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
cartilage development disrupted, abnormal	standard conditions	Fig. 8 from Sperber et al., 2008
cell population proliferation occurrence, normal	standard conditions	Fig. 5 from Jászai et al., 2003
cell proliferation in hindbrain disrupted, abnormal	standard conditions	Fig. 5 from Jászai et al., 2003
cell proliferation in midbrain disrupted, abnormal	standard conditions	Fig. 5 from Jászai et al., 2003
central nervous system development disrupted, abnormal	standard conditions	Fig. 6 from Komisarczuk et al., 2008
ceratobranchial cartilage decreased amount, abnormal	standard conditions	Fig. 4 from Choe et al., 2014
cerebellum absent, abnormal	standard conditions	Fig. 1 , Fig. 7 from Brand et al., 1996
cerebellum aplastic, abnormal	standard conditions	Fig. 9 from Heisenberg et al., 1999 Fig. 8 from Brand et al., 1996
cerebellum morphology, abnormal	control	Fig. 3 from Jászai et al., 2003
cerebellum development decreased process quality, abnormal	standard conditions	Fig. 7 from Reifers et al., 1998
cerebellum development disrupted, abnormal	standard conditions	Fig. 1 , Fig. 3 from Jászai et al., 2003
determination of left/right symmetry disrupted, abnormal	standard conditions	Fig. 8 from Sperber et al., 2008
diencephalon dorsal region dbx1b expression decreased amount, abnormal	control	Fig. 5 from Roberson et al., 2017
diencephalon dorsal region cxcl12b expression decreased distribution, abnormal	control	Fig. 6 from Roberson et al., 2017
diencephalon dorsal region ackr3b expression decreased distribution, abnormal	control	Fig. 6 from Roberson et al., 2017
embryonic pectoral fin morphogenesis process quality, normal	standard conditions	Fig. 11 from Reifers et al., 1998
embryonic retina morphogenesis in camera-type eye decreased process quality, abnormal	standard conditions	Fig. 1 from Picker et al., 2009
embryonic viscerocranium morphogenesis disrupted, abnormal	chemical treatment: dorsomorphin	Fig. 9 from Lovely et al., 2016
embryonic viscerocranium morphogenesis process quality, normal	control	Fig. 9 from Lovely et al., 2016
endocardium present, normal	standard conditions	Fig. 1 from Reifers et al., 2000
fibroblast growth factor receptor signaling pathway process quality, abnormal	control	Fig. 2 from Kapsimali et al., 2011
forebrain neuron normal amount, normal	standard conditions	Fig. 6 from Lam et al., 2003
forebrain neuron spatial pattern, normal	standard conditions	Fig. 6 from Lam et al., 2003
heart decreased length, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
heart dysplastic, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
heart morphology, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
heart development process quality, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
heart rudiment decreased size, abnormal	standard conditions	Fig. 2 from Marques et al., 2008
hindbrain apoptotic, abnormal	standard conditions	Fig. 5 from Jászai et al., 2003
hindbrain blood vessel absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
inner ear decreased size, abnormal	standard conditions	Fig. 7 from Brand et al., 1996 Table 3 from Whitfield et al., 1996
inner ear has fewer parts of type otolith, abnormal	standard conditions	Table 3 from Whitfield et al., 1996
inner ear quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
intermediate mesoderm differentiated, normal	standard conditions	Fig. 10 from Reifers et al., 1998
intersegmental vessel absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
locus ceruleus development disrupted, abnormal	standard conditions	Fig. 6 from Guo et al., 1999
locus coeruleus absent, abnormal	standard conditions	Fig. 6 from Guo et al., 1999
locus coeruleus aplastic, abnormal	control	Fig. 4 from Jászai et al., 2003
locus coeruleus neuron decreased amount, abnormal	standard conditions	Fig. 6 from Lam et al., 2003
mesoderm anterior region has2 expression absent, abnormal	chemical treatment: SU5402	Fig. 8 from McCarthy et al., 2016
midbrain morphology, abnormal	control	Fig. 2 from Jászai et al., 2003
midbrain quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
midbrain hindbrain boundary absent, abnormal	standard conditions	Fig. 1 , Fig. 7 from Brand et al., 1996
midbrain hindbrain boundary aplastic, abnormal	standard conditions	Fig. 1 , Fig. 3 , Fig. 4 from Jászai et al., 2003 Fig. 8 from Brand et al., 1996
midbrain hindbrain boundary morphology, abnormal	standard conditions	Fig. 5 from Nechiporuk et al., 2007
midbrain hindbrain boundary physical object quality, abnormal	standard conditions	Fig. 8 from Reifers et al., 1998
midbrain hindbrain boundary quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
midbrain hindbrain boundary blood vessel absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
midbrain hindbrain boundary neural rod morphology, abnormal	control	Fig. 1 , Fig. 2 from Jászai et al., 2003
midbrain neural rod increased thickness, abnormal	standard conditions	Fig. 7 from Brand et al., 1996
midbrain neural rod morphology, abnormal	control	Fig. 2 from Jászai et al., 2003
midbrain neural rod prominent, abnormal	standard conditions	Fig. 7 from Brand et al., 1996
midbrain-hindbrain boundary development decreased process quality, abnormal	standard conditions	Fig. 7 , Fig. 8 from Reifers et al., 1998
midbrain-hindbrain boundary development disrupted, abnormal	standard conditions	Fig. 5 from Nechiporuk et al., 2007 Fig. 1 , Fig. 2 , Fig. 3 , Fig. 4 from Jászai et al., 2003
myocardium present, normal	standard conditions	Fig. 1 from Reifers et al., 2000
nervous system quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
neurocranium posterior region absent, abnormal	chemical treatment: SU5402	Fig. 8 from McCarthy et al., 2016
optic cup physical object quality, abnormal	standard conditions	Fig. 1 from Picker et al., 2009
optic tectum apoptotic, abnormal	standard conditions	Fig. 5 from Jászai et al., 2003
optic tectum increased size, abnormal	standard conditions	Fig. 1 from Jászai et al., 2003 Fig. 1 , Fig. 7 , Fig. 8 from Brand et al., 1996
optic tectum blood vessel absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
oral epithelium has fewer parts of type taste bud, abnormal	control	Fig. 2 from Kapsimali et al., 2011
otic placode physical object quality, abnormal	standard conditions	Fig. 4 from Mackereth et al., 2005
otic placode formation process quality, abnormal	standard conditions	Fig. 2 from Kwon et al., 2009
otic vesicle agenesis, abnormal	chemical treatment: SB 431542	Fig. 1 from Kwon et al., 2009
otic vesicle hmx3a expression decreased amount, abnormal	standard conditions	Fig. 3 from Adamska et al., 2000
otic vesicle decreased size, abnormal	standard conditions	Fig. 3 from Maier et al., 2014 Fig. 1 from Kwon et al., 2009 Fig. 5 from Hans et al., 2007 Fig. 4 , Fig. 7 from Mackereth et al., 2005
otic vesicle has fewer parts of type otolith, abnormal	standard conditions	Fig. 7 from Mackereth et al., 2005
otic vesicle malformed, abnormal	standard conditions	Fig. 1 from Kwon et al., 2009
otic vesicle formation process quality, abnormal	chemical treatment: SB 431542	Fig. 1 from Kwon et al., 2009
otic vesicle morphogenesis process quality, abnormal	standard conditions	Fig. 4 , Fig. 7 from Mackereth et al., 2005
otolith organ has fewer parts of type otolith, abnormal	standard conditions	Fig. 7 from Brand et al., 1996
pectoral fin bud morphology, normal	standard conditions	Fig. 11 from Reifers et al., 1998
pharyngeal arch morphology, abnormal	standard conditions	Fig. 4 from Plaster et al., 2007
pharyngeal arch blood vessel absent, abnormal	standard conditions	Fig. 1 from Reifers et al., 2000
pharyngeal arch 3-7 morphology, abnormal	standard conditions	Fig. 8 from Sperber et al., 2008
pharyngeal arch 3-7 skeleton disorganized, abnormal	standard conditions	Fig. 4 from Plaster et al., 2007
pharyngeal arch 3-7 skeleton quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
pharyngeal arch cartilage morphology, abnormal	chemical treatment: dorsomorphin	Fig. 9 from Lovely et al., 2016
pharyngeal pouch decreased amount, abnormal	standard conditions	Fig. 4 from Choe et al., 2014
post-vent region curved ventral, abnormal	standard conditions	Table 1 from Brand et al., 1996
post-vent region morphology, normal	standard conditions	Fig. 5 from Plaster et al., 2007
post-vent region mesoderm morphology, abnormal	chemical treatment: trichostatin A	Fig. 8 from Plaster et al., 2007
post-vent region mesoderm morphology, normal	standard conditions	Fig. 5 from Plaster et al., 2007
posterior macula decreased size, abnormal	standard conditions	Fig. 3 from Maier et al., 2014
posterior macula has fewer parts of type hair cell, abnormal	standard conditions	Fig. 3 from Maier et al., 2014
retina development in camera-type eye disrupted, abnormal	standard conditions	Fig. 11 from McMahon et al., 2009
retinal ganglion cell axon guidance disrupted, abnormal	standard conditions	Table 1 from Brand et al., 1996
rhombomere 1 morphology, abnormal	control	Fig. 4 from Jászai et al., 2003
rhombomere 3 decreased thickness, abnormal	control	Fig. 4 from Jászai et al., 2003
rhombomere 5 decreased thickness, abnormal	control	Fig. 4 from Jászai et al., 2003
rostrocaudal neural tube patterning disrupted, abnormal	control	Fig. 4 from Jászai et al., 2003
segmental plate ab2-mapk labeling decreased amount, abnormal	standard conditions	Fig. S1 from Akiyama et al., 2014
segmental plate decreased size, abnormal	chemical treatment: trichostatin A	Fig. 8 from Plaster et al., 2007
semicircular canal truncated, abnormal	standard conditions	Fig. 7 from Brand et al., 1996
sensory system quality, abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)
somite uncx4.1 expression increased distribution, abnormal	standard conditions	Fig. 8 from Nittoli et al., 2019
somite uncx expression increased distribution, abnormal	standard conditions	Fig. 8 from Nittoli et al., 2019
somite poorly differentiated, abnormal	standard conditions	Fig. 10 from Reifers et al., 1998
somite size, normal	control	Fig. 4 from Kok et al., 2010
somite development decreased process quality, abnormal	standard conditions	Fig. 10 from Reifers et al., 1998
somitogenesis process quality, abnormal	standard conditions	Fig. S1 from Akiyama et al., 2014
statoacoustic (VIII) ganglion hmx3a expression absent, abnormal	standard conditions	Fig. 3 from Adamska et al., 2000
taste bud formation decreased process quality, abnormal	control	Fig. 2 from Kapsimali et al., 2011
tegmentum morphology, abnormal	standard conditions	Fig. 8 from Brand et al., 1996
thyroid primordium decreased size, abnormal	standard conditions	Fig. 6 from Wendl et al., 2007
whole organism lacks all parts of type midbrain hindbrain boundary, abnormal	standard conditions	Fig. 7 from Reifers et al., 1998
whole organism lacks all parts of type cerebellum, abnormal	standard conditions	Fig. 7 from Reifers et al., 1998
whole organism lethal (sensu genetics), abnormal	standard conditions	Fig. for (ti282a) from Phenotype Annotation (1994-2006)

CITATIONS (109)