FIGURE

Fig. 3

ID

ZDB-FIG-070416-3

Publication

Krock et al., 2007 - Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia

Other Figures

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Fig. 3

Transmission electron microscopy of 4.5 dpf wild-type and rep1 mutant retinas. (A) Electron micrographs of wild-type retinas reveal an orderly array of photoreceptor outer segments and the uniform thickness of the RPE. Melanosome maturation within the RPE is normal. (B–D) Electron micrographs from multiple rep1 retinas showing degeneration of the RPE and photoreceptors. Arrows in B and C indicate large vacuoles observed in the RPE of rep1 mutants. Arrowheads in D indicate outer segment material not digested by the RPE. Melanosome size and maturation vary more dramatically and are less dense than what is seen in wild type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848
Observed In:	melanosome organization photoreceptor outer segment layer pigmented epithelial cell
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA