FIGURE

Fig. 2

ID

ZDB-FIG-070416-2

Publication

Krock et al., 2007 - Noncell-autonomous photoreceptor degeneration in a zebrafish model of choroideremia

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Fig. 2

Histological sections of 4.5 dpf wild-type and rep1 mutant retinas. (A) Wild-type retinas at 4.5 dpf have fully laminated and retinal ganglion cells (GCL), amacrine and bipolar interneurons (INL), and photoreceptors (ONL) differentiated, and the optic nerve (O.N.) is apparent. (B) Lamination and cellular differentiation is not affected in rep1 mutants, but eye size is reduced and the RPE layer appears irregular. (C) High magnification of sections from light-adapted wild-type retinas showing the rod (r) outer segments positioned distally from the cone (c) outer segments. (D) Sections of rep1 mutants showing areas of RPE hypertrophy (arrows) into the photoreceptor layer and other regions where the RPE is almost devoid of pigmentation (arrowhead). Rod and cone outer segments are not normally positioned and are shorter than wild-type.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	chm^ru848/ru848
Observed In:	eye retinal photoreceptor layer retinal pigmented epithelium retinal pigmented epithelium melanosome
Stage:	Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA