FIGURE

Fig. 1

ID

ZDB-FIG-070307-49

Publication

Kelsh et al., 2000 - The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives

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Fig. 1

Melanoblasts are abnormal in cls^- embryos.
(A) Lateral view of wild-type embryo labeled for dct transcripts at 27 hpf reveals abundant melanoblasts along trunk and tail, with many along medial migration pathway (*). (B) cls^- embryos have fewer melanoblasts, all dorsal to spinal cord (sc). (C) At higher magnification, wild-type melanophores show intense cytoplasmic dct-labeling (purple) and melanosomes (brown granules, arrowhead) in processes. (D) cls^- melanophores show only faint dct labeling. In these and all subsequent lateral views, anterior is to the left and dorsal to the top. At both 24 and 27 hpf cls^- embryos show only approximately one third the number of melanoblasts of wild types (data not shown). m, muscle fibres; n, notochord. Scale bar, 250 μm (A,B) and 50 μm (C,D).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sox10^t3/t3 sox10^tw2/tw2 sox10^tw11/tw11
Observed In:	melanoblast
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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