FIGURE

Fig. 4

ID

ZDB-FIG-070307-52

Publication

Kelsh et al., 2000 - The zebrafish colourless gene regulates development of non-ectomesenchymal neural crest derivatives

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Fig. 4

DRG sensory neurons are disrupted in cls^- larvae. (A-C) Transverse section of dorsal tail of (A) wild-type larva at 7 dpf stained with anti-Hu antibody reveals small clusters of Hu-positive neurons (arrowhead) in DRG. These are usually absent from the tail of cls^- homozygotes (B). cls^- larvae have an increased frequency of extramedullary cells dorsal to the neural tube (nt; arrow in C and G). (D-G) Lateral views of whole-mount larvae at 3 dpf stained with anti-Hu antibody reveal a segmental pattern of DRGs (arrowheads) throughout the trunk (D) and tail (F), but these cells are reduced and misplaced in the trunk (E) and absent from the tail (G) of cls^- larvae. N, notochord; sc, spinal cord. Scale bar, 25 μm (A-C) and 75 μm (D-G).

Expression Data

Antibody:	Ab1-elavl
Fish:	WT sox10^t3/t3
Anatomical Terms:	dorsal root ganglion sensory neuron post-vent region dorsal root ganglion
Stage Range:	Protruding-mouth to Days 7-13

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sox10^t3/t3 sox10^tw2/tw2 sox10^tw11/tw11
Observed In:	dorsal root ganglion
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

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