FIGURE

Fig. 6

ID

ZDB-FIG-070219-23

Publication

Millimaki et al., 2007 - Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch

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Fig. 6

Heat-shock induction of NICD. (A-D) Expression of atoh1b and ngn1 at 11 hpf (A,B) and 12 hpf (C,D) in control embryos (A,C) or NICD-positive embryos (B,D) heat shocked at 9 hpf. Loss of ngn1 expression, which is non-overlapping with atoh1b, confirms effective NICD-induction. (E-H) Expression of atoh1a at 19 hpf (E,F) and 20 hpf (G,H) in atoh1b morphants without NICD (E,G) or with NICD (F,H) heat shocked at 18 hpf. Otic vesicles are outlined. Arrowheads mark otic expression domains. All are lateral views with anterior to the left. Scale bar: 15 μm. tg, trigeminal ganglion.

Expression Data

Genes:	atoh1a atoh1b neurog1
Fish:	WT WT + MO1-atoh1b kca3Tg/+; kca4Tg/+ kca3Tg/+; kca4Tg/+ + MO1-atoh1b
Condition:	heat shock
Knockdown Reagent:	MO1-atoh1b
Anatomical Terms:	otic placode otic vesicle trigeminal placode
Stage Range:	1-4 somites to 20-25 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	kca3Tg/+; kca4Tg/+ + MO1-atoh1b
Condition:	heat shock
Knockdown Reagent:	MO1-atoh1b
Observed In:	hair cell
Stage:	20-25 somites

Phenotype Detail

Acknowledgments

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