ZFIN Morpholino: MO1-atoh1b

Target Location

Genome Build: GRCz11Chromosome: KN150642.1

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-atoh1b

No data available

Phenotype

Phenotype resulting from MO1-atoh1b

Phenotype	Fish	Figures
hair cell decreased amount, abnormal	AB + MO1-atoh1b	Fig. 2 from Millimaki et al., 2007
otic vesicle lacks all parts of type tether cell, abnormal	WT + MO1-atoh1b	Fig. 5 from Stooke-Vaughan et al., 2015

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Phenotype of all Fish created by or utilizing MO1-atoh1b

Phenotype	Fish	Conditions	Figures
hair cell decreased amount, abnormal	AB + MO1-atoh1b	standard conditions	Fig. 2 from Millimaki et al., 2007
otic vesicle lacks all parts of type tether cell, abnormal	WT + MO1-atoh1b	standard conditions	Fig. 5 from Stooke-Vaughan et al., 2015
hair cell absent, abnormal	AB + MO1-atoh1b + MO4-atoh1a	standard conditions	Fig. 2 from Millimaki et al., 2007
hair cell absent, abnormal	mib1^ta52b/ta52b + MO1-atoh1b + MO4-atoh1a	standard conditions	Fig. 4 from Millimaki et al., 2007
hair cell absent, abnormal	kca3Tg/+; kca4Tg/+ + MO1-atoh1b	heat shock	Fig. 6 from Millimaki et al., 2007

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Citations

Include unpublished citations

Ezhkova, D., Schwarzer, S., Spieß, S., Geffarth, M., Machate, A., Zöller, D., Stucke, J., Alexopoulou, D., Lesche, M., Dahl, A., Hans, S. (2023) Transcriptome analysis reveals an Atoh1b-dependent gene set downstream of Dlx3b/4b during early inner ear development in zebrafish. Biology Open. 12(6):
Stooke-Vaughan, G.A., Obholzer, N.D., Baxendale, S., Megason, S.G., Whitfield, T.T. (2015) Otolith tethering in the zebrafish otic vesicle requires Otogelin and α-Tectorin. Development (Cambridge, England). 142(6):1137-45
Wang, J., Wu, Y., Zhao, F., Wu, Y., Dong, W., Zhao, J., Zhu, Z., Liu, D. (2015) Fgf-signaling-dependent sox9a and atoh1a regulate otic neural development in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:234-44
Radosevic, M., Fargas, L., Alsina, B. (2014) The Role of her4 in Inner Ear Development and Its Relationship with Proneural Genes and Notch Signalling. PLoS One. 9:e109860
Stooke-Vaughan, G.A., Huang, P., Hammond, K.L., Schier, A.F., and Whitfield, T.T. (2012) The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle. Development (Cambridge, England). 139(10):1777-1787
Yu, X., Lau, D., Ng, C.P., and Roy, S. (2011) Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear. Development (Cambridge, England). 138(3):487-494
Matsuda, M., and Chitnis, A.B. (2010) Atoh1a expression must be restricted by Notch signaling for effective morphogenesis of the posterior lateral line primordium in zebrafish. Development (Cambridge, England). 137(20):3477-3487
Millimaki, B.B., Sweet, E.M., and Riley, B.B. (2010) Sox2 is required for maintenance and regeneration, but not initial development, of hair cells in the zebrafish inner ear. Developmental Biology. 338(2):262-269
Millimaki, B.B., Sweet, E.M., Dhason, M.S., and Riley, B.B. (2007) Zebrafish atoh1 genes: classic proneural activity in the inner ear and regulation by Fgf and Notch. Development (Cambridge, England). 134(2):295-305

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