FIGURE

Fig. 6

ID

ZDB-FIG-060825-11

Publication

Koudijs et al., 2005 - The Zebrafish Mutants dre, uki, and lep Encode Negative Regulators of the Hedgehog Signaling Pathway

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Fig. 6

Premature Stop Codons Were Identified in the uki and lep Mutant in Hip and Ptc2, Respectively
(A) Schematic representation of the genomic organization of the Hip gene. All three alleles of the uki mutation contain premature stop codons positioned in exon 5 and exon 7.
(B) Representation of the protein structure of Ptc2 shows that the identified nonsense mutation is positioned after the sixth transmembrane domain, probably resulting in a malfunctioning protein.
(C) ISH experiments show that Ptc1 expression is increased in uki and lep (arrow), confirming the aberrant activation of the Hh signaling pathway.

Expression Data

Gene:	ptch2
Fish:	WT hhip^{hu418b/hu418b} ptch1^tj222/tj222
Anatomical Term:	unspecified
Stage:	Prim-25

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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