FIGURE

Fig. 4

ID

ZDB-FIG-060203-19

Publication

Cunliffe et al., 2006 - Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS

Other Figures

(all 7)

All Figure Page

Back to All Figure Page

Fig. 4

The up-regulation of nkx2.2a expression in the ventral hindbrain that is caused by loss of hdac1 function is strictly smoothened-dependent. Expression of nkx2.2a at 25 hpf in hindbrain of (A) wild-type sibling embryo microinjected with an hdac1 control-MO, (B) homozygous smoothened mutant embryo microinjected with hdac1 control-MO, (C) wild-type sibling embryo microinjected with an hdac1-specific MO and (D) homozygous smoothened mutant embryo microinjected with an hdac1-specific MO. Panels show transverse sections through the hindbrain of 25 hpf embryos at the level of rhombomere 5.

Expression Data

Gene:	nkx2.2a
Fish:	WT + MO1-hdac1 smo^hi1640Tg + MO1-hdac1
Knockdown Reagent:	MO1-hdac1
Anatomical Term:	hindbrain
Stage:	Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Mechanisms of Development, 123(1), Cunliffe, V.T., and Casaccia-Bonnefil, P., Histone deacetylase 1 is essential for oligodendrocyte specification in the zebrafish CNS, 24-30, Copyright (2006) with permission from Elsevier. Full text @ Mech. Dev.