CRISPR

CRISPR1-dhx38

ID

ZDB-CRISPR-240827-1

Name

CRISPR1-dhx38

Previous Names

None

Target

dhx38 (1)

Sequence

5' - GCCTTCTAGCCGGTGCAGGG - 3'

Disclaimer

Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.

Note

None

Genome Resources

None

Target Location

Constructs

No data available

Genomic Features

Genomic Feature	Affected Genomic Regions
hzu20	dhx38
zf4116	dhx38

Expression

Gene expression in Wild Types + CRISPR1-dhx38

No data available

Phenotype

Phenotype resulting from CRISPR1-dhx38

No data available

Phenotype of all Fish created by or utilizing CRISPR1-dhx38

Phenotype	Fish	Conditions	Figures
whole organism cdkn1a expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
whole organism masp1 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
semicircular canal dacha expression absent, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
otolith otomp expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
inner ear development disrupted, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 1 , Figure 2 from Ren et al., 2024
whole organism bbc3 expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
whole organism spns2 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
inner ear apoptotic process increased occurrence, ameliorated	dhx38^hzu20/hzu20	chemical treatment by environment: p53 inhibitor	Figure 3 from Ren et al., 2024
whole organism casp8 expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
whole organism bcl2a expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
inner ear smc5 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
inner ear eme1 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
whole organism col11a2 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
inner ear nuclear chromosome damaged, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 4 from Ren et al., 2024
inner ear slx4 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
otolith otomp expression decreased distribution, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
otic vesicle protrusion absent, ameliorated	dhx38^hzu20/hzu20	chemical treatment by environment: p53 inhibitor	Figure 3 from Ren et al., 2024
whole organism gadd45ba expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
inner ear rad17 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
whole organism ret expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
inner ear rad9a expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
inner ear tonsl expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
inner ear foxj1b expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
otolith stm expression decreased distribution, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
inner ear foxm1 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
whole organism cep290 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
otolith stm expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
otic vesicle protrusion absent, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 1 , Figure 3 from Ren et al., 2024
whole organism smad5 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
inner ear blm expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
inner ear mRNA splicing, via endonucleolytic cleavage and ligation disrupted, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 , Figure 6 from Ren et al., 2024
semicircular canal bmp4 expression absent, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
whole organism pax2a expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 6 from Ren et al., 2024
inner ear apoptotic process increased occurrence, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
whole organism tp53 expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
inner ear fanci expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
saccule cahz expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
semicircular canal ncs1a expression absent, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
macula utricle cahz expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 2 from Ren et al., 2024
inner ear ints7 expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024
otic vesicle decreased size, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 1 , Figure 3 from Ren et al., 2024
otolith decreased size, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 1 from Ren et al., 2024
otic vesicle size, ameliorated	dhx38^hzu20/hzu20	chemical treatment by environment: p53 inhibitor	Figure 3 from Ren et al., 2024
whole organism mdm2 expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
whole organism baxa expression increased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 3 from Ren et al., 2024
inner ear mms22l expression decreased amount, abnormal	dhx38^hzu20/hzu20	standard conditions	Figure 5 from Ren et al., 2024

Citations