FIGURE SUMMARY
Title

Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure

Authors
Thunga, P., Truong, L., Rericha, Y., Du, J., Morshead, M., Tanguay, R.L., Reif, D.M.
Source
Full text @ Toxics
Figure 1

Experimental setup for direct embryonic exposure study (zebrafish embryos exposed to control, 16.4 μM or 74.8 μM of PFHxA from @ 6hpf; phenotypic measurements, i.e., behavioral assessments at 120hpf; developmental assessments of 13 specific morphology endpoints at 120 hpf) for a single test chemical. LPR–Larval Photomotor Response assay. (Figure created with Biorender.com).
Figure 2

(A) Box plot showing total distance moved during dark phase of LPR assay broken down by pairs from each exposure group. (B) Variance Component Estimates. Bar plot showing percent of total variance explained by Family ID in each exposure group.
Figure 3

tSNE of normalized gene expression counts of genes that had a significant GxE effect. Color of the points represent family and shape represents exposure. Shades of blue are controls; shades of green represent medium PFHxA groups, and shades of pink represent high PFHxA groups.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Toxics
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