ZFIN All Figures, Fogerty <i>et al.</i>, 2022

Fig. 1

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	EGFP GFP
Antibody:	zpr-1
Fish:	mi2002Tg cep290^fh297/fh297; fl1Tg cep290^fh297/fh297; mi2002Tg
Anatomical Terms:	Muller cell retinal cone cell retinal rod cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	cep290^fh297/fh297; fl1Tg cep290^fh297/fh297; mi2002Tg
Observed In:	retinal inner nuclear layer stem cell proliferation retinal outer nuclear layer Muller cell retinal outer nuclear layer stem cell proliferation retinal rod cell cell population proliferation retinal rod cell sensory epithelium regeneration
Stage:	Adult

Phenotype details

Fig. 2

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Antibodies:	Ab-4C4 Ab5-lcp1
Fish:	WT cep290^fh297/fh297
Anatomical Term:	retina microglial cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	cep290^fh297/fh297
Observed In:	microglial cell retina distal region retina microglial cell retina microglial cell activation retina peripheral region retinal inner plexiform layer retinal outer plexiform layer
Stage:	Adult

Phenotype details

Fig. 3

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Genes:	hmga1a notch3 stat3 tnfa yap1
Fish:	WT cep290^fh297/fh297 gmc500Tg
Condition:	chemical treatment by environment: metronidazole
Anatomical Terms:	Muller cell retina
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	cep290^fh297/fh297 gmc500Tg
Condition:	chemical treatment by environment: metronidazole
Observed In:	Muller cell retina
Stage:	Adult

Phenotype details

Fig. 4

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 5

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Gene:	EGFP
Fish:	mi35Tg cep290^fh297/fh297; mi35Tg
Condition:	perforation: retina
Anatomical Term:	Muller cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	mi35Tg cep290^fh297/fh297; mi35Tg
Condition:	perforation: retina
Observed In:	Muller cell retina cell population proliferation
Stage:	Adult

Phenotype details

Fig. 6

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Gene:	GFP
Fish:	mi2002Tg cep290^fh297/fh297; mi2002Tg
Condition:	light damage: retina
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	mi2002Tg cep290^fh297/fh297; mi2002Tg
Condition:	light damage: retina
Observed In:	retinal inner nuclear layer Muller cell retinal inner nuclear layer stem cell proliferation retinal outer nuclear layer Muller cell retinal outer nuclear layer stem cell proliferation
Stage:	Adult

Phenotype details

Fig. 7

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Antibodies:	zpr-1 zpr-3
Fish:	WT cep290^fh297/fh297
Condition:	light damage: retina
Anatomical Terms:	retinal cone cell retinal rod cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	WT cep290^fh297/fh297
Condition:	light damage: retina
Observed In:	retinal cone cell sensory epithelium regeneration retinal rod cell sensory epithelium regeneration
Stage:	Adult

Phenotype details

Fig. 8

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Antibody:	zpr-1
Fish:	WT cep290^fh297/fh297
Condition:	light damage: retina
Anatomical Terms:	retina leukocyte retinal cone cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	WT cep290^fh297/fh297
Condition:	light damage: retina
Observed In:	retina retinal cone cell retinal cone cell sensory epithelium regeneration
Stage:	Adult

Phenotype details

Fig. 9

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Antibodies:	Ab-4C4 Ab5-lcp1
Fish:	WT cep290^fh297/fh297
Conditions:	chemical treatment by environment: dexamethasone chemical treatment by environment: mifepristone
Anatomical Terms:	retina leukocyte retina microglial cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	WT cep290^fh297/fh297
Conditions:	chemical treatment by environment: dexamethasone chemical treatment by environment: mifepristone
Observed In:	microglial cell retina microglial cell activation retina peripheral region retinal inner nuclear layer cell population proliferation retinal neural layer retinal outer nuclear layer cell population proliferation
Stage:	Adult

Phenotype details

Fig. 10

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Antibody:	Ab-4C4
Fish:	WT irf8^st95/st95
Anatomical Term:	retina microglial cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	irf8^st95/st95
Observed In:	microglial cell retina
Stage:	Adult

Phenotype details

Fig. 11

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:

Antibodies:	Ab-4C4 Ab5-lcp1 zpr-1
Fish:	WT cep290^fh297/fh297 irf8^st95/st95 cep290^fh297/fh297; irf8^st95/st95
Anatomical Terms:	retina leukocyte retina microglial cell retinal cone cell
Stage:	Adult

Expression / Labeling details

PHENOTYPE:

Fish:	cep290^fh297/fh297 irf8^st95/st95 cep290^fh297/fh297; irf8^st95/st95
Observed In:	microglial cell retina retina cell population proliferation retinal cone cell retinal outer nuclear layer cell population proliferation
Stage:	Adult

Phenotype details

Fig. 12

ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

PHENOTYPE:

Fish:	WT cep290^fh297/fh297
Condition:	chemical treatment by environment: mifepristone, chemical treatment by injection: RO4929097
Observed In:	retinal inner nuclear layer stem cell proliferation retinal outer nuclear layer stem cell proliferation
Stage:	Adult

Phenotype details

Acknowledgments

Full text @ J. Neurosci.

Fogerty et al., 2022

ZDB-PUB-220608-11
PMID:35672150

Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy

Fogerty et al., 2022 ZDB-PUB-220608-11 PMID:35672150

Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophy

Fogerty et al., 2022

ZDB-PUB-220608-11
PMID:35672150