Gene
yap1
- ID
- ZDB-GENE-030131-9710
- Name
- Yes1 associated transcriptional regulator
- Symbol
- yap1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables transcription coactivator activity. Involved in several processes, including dorsal/ventral axis specification; embryonic hemopoiesis; and heart formation. Acts upstream of with a positive effect on BMP signaling pathway. Acts upstream of or within several processes, including Kupffer's vesicle development; circulatory system development; and sensory system development. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; digestive system; mesoderm; sensory system; and tail bud. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb194 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 50 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
bns19 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | CRISPR | |
bns22 | Allele with one deletion | Unknown | Unknown | CRISPR | |
fu47 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
fu48 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
la013286Tg | Transgenic insertion | Unknown | Unknown | DNA | |
la020426Tg | Transgenic insertion | Unknown | Unknown | DNA | |
mw48 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
mw69 | Allele with one deletion | Unknown | Unknown | TALEN | |
ncv101 | Allele with one deletion | Exon 1 | Premature Stop | TALEN | |
ncv117 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
uveal coloboma-cleft lip and palate-intellectual disability | Alliance | Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development | 120433 |
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Human Disease | Fish | Conditions | Citations |
---|---|---|---|
coloboma | yap1nl13/nl13 | standard conditions | Miesfeld et al., 2015 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | TEAD interating region 3, omega loop | WW domain | WW domain superfamily | Yes-associated protein 1 |
---|---|---|---|---|---|---|
UniProtKB:Q1L8J7 | InterPro | 442 | ||||
UniProtKB:A0A8M2BKX9 | InterPro | 404 |
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Interactions and Pathways
No data available
Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
---|---|---|---|---|---|---|---|
Ab2-yap1 | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
7 | |
Ab1-yap1 | polyclonal | Rabbit |
|
Cell Signaling Technology, Inc.
|
18 |
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Plasmids
Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
---|---|---|---|---|---|
Tg(-2.8fabp10a:yap1_S87A,cryaa:Venus) |
|
| 1 | (3) | |
Tg(14xUAS:DsRed,NLS-dnyap1) |
| 1 | Miesfeld et al., 2015 | ||
Tg(14xUAS:DsRed,yap1) |
|
| 1 | (3) | |
Tg(14x-UAS:DsRed,yap1_S87A) |
|
| 1 | (4) | |
Tg(cdh17:yap1-EGFP) |
|
| 1 | Xu et al., 2018 | |
Tg(cdh17:yap1_S87A-EGFP) |
|
| 1 | Xu et al., 2018 | |
Tg(cdh17:yap1_S87D-EGFP) |
|
| 1 | Xu et al., 2018 | |
Tg(CMV:yap1_S87A,GFP) |
|
| 1 | (2) | |
Tg(hsp70l:LOXP-TagBFP-LOXP-NLS-dnyap1-2A-mCherry) |
| 1 | (2) | ||
Tg(hsp70l:RFP-cayap1) |
|
| 1 | (5) |
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Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-3B8 | ZFIN Curated Data | |
Encodes | EST | cb194 | Thisse et al., 2001 | |
Encodes | EST | fc18c04 | ZFIN Curated Data | |
Encodes | cDNA | MGC:158380 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001139480 (1) | 3940 nt | ||
Genomic | GenBank:AL954841 (1) | 149277 nt | ||
Polypeptide | UniProtKB:Q1L8J7 (2) | 442 aa |
- Dicipulo, R., Selland, L.G., Carpenter, R.G., Waskiewicz, A.J. (2025) Functional role for Taz during hindbrain ventricle morphogenesis. PLoS One. 20:e0313262e0313262
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Albu, M., Affolter, E., Gentile, A., Xu, Y., Kikhi, K., Howard, S., Kuenne, C., Priya, R., Gunawan, F., Stainier, D.Y.R. (2024) Distinct mechanisms regulate ventricular and atrial chamber wall formation. Nature communications. 15:81598159
- Chen, M., Liu, Y., Zuo, M., Guo, C., Du, Y., Xu, H., Liu, B., Li, M., Xiao, W., Yu, G. (2024) NEDD8 enhances Hippo signaling by mediating YAP1 neddylation. The Journal of biological chemistry. 300(8):107512
- Dai, C., Zhang, Y., Gong, Y., Bradley, A., Tang, Z., Sellick, K., Shrestha, S., Spears, E., Covington, B.A., Stanley, J., Jenkins, R., Richardson, T.M., Brantley, R.A., Coate, K., Saunders, D.C., Wright, J.J., Brissova, M., Dean, E.D., Powers, A.C., Chen, W. (2024) Hyperaminoacidemia from interrupted glucagon signaling increases pancreatic acinar cell proliferation and size via mTORC1 and YAP pathways. iScience. 27:111447111447
- Dong, Y., Yang, Y., Wang, H., Feng, D., Nist, E., Yapundich, N., Spurlock, B., Craft, M., Qian, L., Liu, J. (2024) Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells. Science advances. 10:eadk4694
- Guo, X., Yang, L., Wang, Y., Yuan, M., Zhang, W., He, X., Wang, Q. (2024) Wnt2bb signaling promotes pharyngeal chondrogenic precursor proliferation and chondrocyte maturation by activating Yap expression in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. :
- Li, M., Wang, R., Yan, T., Tao, X., Gao, S., Wang, Z., Chai, Y., Qiu, S., Chen, W. (2024) Dual effects of DLG5 (disks large homolog 5 gene) modulation on chemotherapy-induced thrombocytopenia and nausea/vomiting via the hippo signalling pathway. British journal of pharmacology. 182(4):1090-1106
- Lu, C., Hyde, D.R. (2024) Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retina. Frontiers in cell and developmental biology. 12:14063301406330
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
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