Gene
yap1
- ID
- ZDB-GENE-030131-9710
- Name
- Yes1 associated transcriptional regulator
- Symbol
- yap1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Enables transcription coactivator activity. Involved in several processes, including dorsal/ventral axis specification; embryonic hemopoiesis; and heart formation. Acts upstream of with a positive effect on BMP signaling pathway. Acts upstream of or within several processes, including Kupffer's vesicle development; circulatory system development; and sensory system development. Located in chromatin and nucleus. Is expressed in several structures, including central nervous system; digestive system; mesoderm; sensory system; and tail bud. Used to study coloboma. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 31 figures from 20 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb194 (12 images)
Wild Type Expression Summary
- All Phenotype Data
- 50 figures from 21 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| uveal coloboma-cleft lip and palate-intellectual disability | Alliance | Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development | 120433 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| coloboma | yap1nl13/nl13 | standard conditions | Miesfeld et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | TEAD interating region 3, omega loop | WW domain | WW domain superfamily | Yes-associated protein 1 |
|---|---|---|---|---|---|---|
| UniProtKB:Q1L8J7 | InterPro | 442 | ||||
| UniProtKB:A0A8M2BKX9 | InterPro | 404 |
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab2-yap1 | monoclonal | IgG2a | Mouse |
|
Santa Cruz Biotechnology, Inc.
|
7 | |
| Ab1-yap1 | polyclonal | Rabbit |
|
Cell Signaling Technology, Inc.
|
18 |
Plasmids