ZFIN All Figures, Dong <i>et al.</i>, 2021

Dong et al., 2021

ZDB-PUB-210326-2
PMID:33761877
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FIGURE SUMMARY

Title: Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer's disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis
Authors: Dong, Y., Newman, M., Pederson, S.M., Barthelson, K., Hin, N., Lardelli, M.
Source: Full text @ BMC Genomics

Fig. 1

Mating scheme to generate pairs of 7 dpf zebrafish larval clutches

Fig. 2

a PCA plots before (left) and after (right) RUV treatment, showing the separation between wild type and mutant larvae across principle components PC1 and PC2. Each sample is labelled by pair (i.e. B, D, F, G, H, or I). b A volcano plot highlighting identified DE genes in red. The DE genes with absolute log₂FC > ±1.2 are labelled on the plot. The black vertical lines indicate absolute log₂FC = ±0.5. c A plot of percent variation summarizing the contribution of each variable

Fig. 3

Network of relationships between DE genes and significantly-changed GO terms in the Goseq analysis. Dots represent DE genes and are labelled with gene names. Numbered circles represent those GO terms showing significant enrichment for the DE genes. The table below the network indicates the GO represented by each number

Fig. 4

Diagrams for four significantly-changed KEGG pathways plotted using pathview [35]. a DNA replication. b cell cycle. c ECM receptor interaction. d oxidative phosphorylation. Intensity of colour represents gene log₂FC with downregulation in green and upregulation in red. Pathway maps are displayed with copyright permission from KEGG

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Genomics

Dong et al., 2021 ZDB-PUB-210326-2 PMID:33761877

Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer's disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis

Dong et al., 2021

ZDB-PUB-210326-2
PMID:33761877