- Title
-
Enhancing the anti-glioma therapy of doxorubicin by honokiol with biodegradable self-assembling micelles through multiple evaluations
- Authors
- Gao, X., Yu, T., Xu, G., Guo, G., Liu, X., Hu, X., Wang, X., Liu, Y., Mao, Q., You, C., Zhou, L.
- Source
- Full text @ Sci. Rep.
Anti-angiogenic effects of HK-Dox/MPEG-PCL. Normal embryos (A), embryos treated with empty MPEG-PCL (B), embryos treated with HK/MPEG-PCL micelles (C), embryos treated with Dox/MPEG-PCL micelles (D), and embryos treated with HK-Dox/MPEG-PCL micelles (E). Embryos treated with HK-Dox/MPEG-PCL micelles showed defective vascular formation of variable severity, with intersegmental vessels either sprouting abnormally or failing to form in comparison with control embryos. |
Antitumor effects of Dox-HK/MPEG-PCL in zebrafish tumor models. Zebrafish were injected with 300 tumor cells into the perivitelline space using a Cell Tram Vario injector with a glass micropipette. At 24 h post-implantation, Tumors from zebrafish treated with NS, empty micelles (EM), HK-M, Dox-M, or Dox-HK-M micelles are shown. The Dox-HK/MPEG-PCL micelles inhibited tumor growth in zebrafish more effectively than other groups. |