ZFIN Human Disease: osteoporosis

OBO ID: DOID:11476

OBO ID: DOID:11476

Term Name:	osteoporosis	Search Ontology:
Synonyms:
Definition:	A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. (4)
References:	EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 MESH:D010024 NCI:C3298 OMIM:166710 SNOMEDCT_US_2023_03_01:156825006 UMLS_CUI:C0029456
Ontology:	Human Disease ( DOID:11476 )

Relationships

is a type of:	bone resorption disease bone resorption disease Show first 5 Terms
has subtype:	glucocorticoid-induced osteoporosis idiopathic juvenile osteoporosis glucocorticoid-induced osteoporosis idiopathic juvenile osteoporosis Show first 5 Terms

OTHER osteoporosis PAGES

Alliance (1)

GENES INVOLVED

Human Gene	Zebrafish Ortholog	OMIM Term	OMIM Phenotype ID
CALCR	calcr	{Osteoporosis, postmenopausal, susceptibility}	166710
COL1A1	col1a1b col1a1a	{Bone mineral density variation QTL, osteoporosis}	166710
COL1A2	col1a2	{Osteoporosis, postmenopausal}	166710
PDLIM4	pdlim4	{Osteoporosis, susceptibility to}	166710

ZEBRAFISH MODELS

Fish	Conditions	Citations
AB	chemical treatment by environment: dexamethasone	Xue et al., 2020
	chemical treatment by environment: etidronate disodium	Xue et al., 2019
	chemical treatment by environment: prednisone	Zhou et al., 2023
	chemical treatment by environment: prednisolone	Karunarathne et al., 2021
	chemical treatment by environment: prednisolone	Liu et al., 2020
	chemical treatment by environment: prednisone	Wang et al., 2018
	chemical treatment by environment: prednisolone	Zang et al., 2021
	chemical treatment by environment: prednisolone	Wang et al., 2019
	chemical treatment by injection: streptozocin	Xu et al., 2022
WT	chemical treatment: dexamethasone	Yin et al., 2017
	chemical treatment by environment: dexamethasone	Hu et al., 2022
	chemical treatment by environment: dexamethasone	Zheng et al., 2017
	chemical treatment by environment: prednisolone	Yang et al., 2019
	chemical treatment by environment: prednisolone	Lee et al., 2020
	chemical treatment by environment: prednisolone	Wu et al., 2017
	chemical treatment by environment: prednisolone	Wang et al., 2018
atp6v1h^la439/la439	standard conditions	Zhang et al., 2017
foxl1^nfl1/nfl1 (AB)	standard conditions	Hawkey-Noble et al., 2022
lrp5^{sa11097/sa11097} (AB)	standard conditions	Bek et al., 2021
AB + CRISPR3-lrp5	control	Bek et al., 2021

PHENOTYPE No data available

CITATIONS (32)