Publication	Data		Fish	Anatomy
Lin et al., 2021	Fig. 2		kars1omf1/omf1 (NHGRI-1)	eye decreased size, abnormal head decreased size, abnormal otic vesicle decreased size, abnormal pericardium edematous, abnormal startle response arrested, abnormal swim bladder uninflated, abnormal whole organism dead, abnormal
	Fig. 3		kars1omf1/omf1 (NHGRI-1)	brain has fewer parts of type neuron, abnormal brain segmentation disrupted, abnormal brain spongy, abnormal brain vacuolated, abnormal eye decreased volume, abnormal immature anterior macula flattened, abnormal immature posterior macula flattened, abnormal inner ear has fewer parts of type inner ear stereocilium, abnormal motor neuron axon terminus decreased branchiness, abnormal motor neuron neuron projection decreased size, abnormal otic vesicle decreased size, abnormal otolith decreased size, abnormal primary motor neuron axon decreased diameter, abnormal retina layer formation disrupted, abnormal retina morphology, abnormal trunk musculature muscle cell morphology, abnormal
	Fig. 4		kars1omf1/omf1 (NHGRI-1) ,   NHGRI-1 + CRISPR3-kars1 + CRISPR4-kars1 + CRISPR5-kars1 + CRISPR6-kars1 + CRISPR7-kars1	brain apoptotic process increased occurrence, abnormal brain spongy, abnormal brain vacuolated, abnormal eye apoptotic process increased occurrence, abnormal eye decreased size, abnormal eye decreased volume, abnormal head decreased size, abnormal inner ear apoptotic process increased occurrence, abnormal retina layer formation disrupted, abnormal retina morphology, abnormal trunk apoptotic process increased occurrence, abnormal whole organism casp8 expression increased amount, abnormal whole organism casp9 expression increased amount, abnormal whole organism gnb3b expression decreased amount, abnormal whole organism grk7a expression decreased amount, abnormal whole organism mbpa expression decreased amount, abnormal whole organism neurod1 expression decreased amount, abnormal whole organism viability, abnormal
	Fig. S12		kars1omf1/omf1 (NHGRI-1)	whole organism aimp1b expression increased amount, abnormal whole organism aimp2 expression increased amount, abnormal whole organism casp8 expression increased amount, abnormal whole organism casp9 expression increased amount, abnormal whole organism dars1 expression increased amount, abnormal whole organism eprs1 expression increased amount, abnormal whole organism gars1 expression increased amount, abnormal whole organism gnb3b expression decreased amount, abnormal whole organism grk7a expression decreased amount, abnormal whole organism hars expression increased amount, abnormal whole organism iars1 expression increased amount, abnormal whole organism lars1b expression increased amount, abnormal whole organism mars1 expression increased amount, abnormal whole organism mbpa expression decreased amount, abnormal whole organism neurod1 expression decreased amount, abnormal whole organism neurod2 expression decreased amount, abnormal whole organism qars1 expression increased amount, abnormal whole organism rars1 expression increased amount, abnormal whole organism rbp2a expression decreased amount, abnormal whole organism stxbp1b expression decreased amount, abnormal whole organism tp53 expression increased amount, abnormal whole organism tulp1b expression decreased amount, abnormal whole organism yars1 expression increased amount, abnormal
	Fig. S6		kars1omf3/omf3 (NHGRI-1) ,   kars1omf2/omf2 (NHGRI-1) ,   kars1omf1/omf1 (NHGRI-1)	whole organism kars1 expression decreased amount, abnormal
	Fig. S7		kars1omf3/omf3 (NHGRI-1) ,   kars1omf2/omf2 (NHGRI-1) ,   kars1omf1/omf1 (NHGRI-1)	eye decreased size, abnormal head decreased size, abnormal otic vesicle decreased size, abnormal otolith decreased size, abnormal pericardium edematous, abnormal swim bladder uninflated, abnormal thigmotaxis arrested, abnormal whole organism dead, abnormal
	Fig. S8		kars1omf1/omf1 (NHGRI-1)	posterior lateral line neuromast has fewer parts of type neuromast hair cell, abnormal whole organism fosab expression increased amount, abnormal
Phenotype Annotation (1994-2006)	Fig. for (hi2586)		kars1hi2586Tg	eye decreased size, abnormal gut quality, abnormal heart quality, abnormal liver quality, abnormal
Amsterdam et al., 2004	text only		kars1hi2586Tg/hi2586Tg	eye decreased size, abnormal gut hypoplastic, abnormal head decreased size, abnormal liver hypoplastic, abnormal pericardium edematous, abnormal trunk degenerate, abnormal