FIGURE SUMMARY
- Title
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Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor
- Authors
- Narasimhan, S., Stanford Zulick, E., Novikov, O., Parks, A.J., Schlezinger, J.J., Wang, Z., Laroche, F., Feng, H., Mulas, F., Monti, S., Sherr, D.H.
- Source
- Full text @ Int. J. Mol. Sci.
AHR inhibitors block human cancer cell metastasis in zebrafish xenograft models. Human RFP-MDA-MB-231 (TNBC), RFP-HSC3 (oral squamous cell carcinoma), or RFP-HeLa (cervical carcinoma) cells were injected into the perivitiline space of two-day-old zebrafish larvae and larvae were treated with vehicle (0.1% DMSO), 10 μM CB7993113 or 10 μM CH223191. Fish were imaged 24 h later at 8.5× magnification by confocal microscopy. (A) Representative images from 9–20 fish/group. (B) The number of fish with one or more metastases. (C) Data are presented as the average number of metastases/fish + SE after treatment with vehicle, CB7993113 (CB) or CH223191 (CH). * p = 0.08, ** p < 0.02, *** p < 0.003.
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DIM inhibits metastasis in zebrafish larvae xenografts. RFP-HeLa cells were injected into the perivitiline space of two-day-old zebrafish larvae and larvae treated with vehicle (0.1% DMSO) or 1, 5, or 10 μM DIM (2–3 larvae/dose). Fish were imaged 24 h later at 8.5× magnification by confocal microscopy. (A) Left and right: two representative images from each group with 5–7 fish/group. (B) Number of fish with brain or tail metastases. (C) The number of metastases per fish were quantified and presented here as the average number of brain (left) or tail (right) metastases/fish + SE after treatment with vehicle (0.1% DMSO) or 1–10 μM DIM. * p < 0.05. ** p < 0.01.
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Full text @ Int. J. Mol. Sci.