Genomic Feature
dhkz1a
- ID
- ZDB-ALT-170630-4
- Name
- dhkz1a
- Synonyms
- None
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one deletion (1)
- Protocol
- embryos treated with
- Lab of Origin
- Laboratory of Dr. Andrew L. Miller
- Current Source
- Other Pages
Notes
No data available
Variants
- Variant Type
- Small Deletion
- Variant Location
- Chr 7: 55043332 - 55043339 (GRCz11) (1) Details
- Nucleotide change
- GCTATCTC/-
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- 8 bp deleted in Exon 9 (1)
- Transcript Consequence
- Frameshift, Premature Stop (1)
- Protein Consequence
- None
- Flanking Sequence
-
AAACTTTCTGAGAGAAAAAACGCAGGCACTGGACAGGGTTGATTGAGCCTGGTTTATACTTCTGCGATGTGTAGTTACATTTTTTGAGAGGTGCACGTCAGTAACAGCCACATCAAGGACTATGCGAGCACACTCCGCCGGATAATATGCGTGAGCTTGTACTGTACACTACACACTTATGACGCATTAGAAGTTATTCATAATAATACTTAGAAGTATAAGTGCTAATAAAAAAAATAAAATCAAATGATGTGCGTGTGATAACTTATTACATCTGATTTGGCAAAGATCAGCATTCCAATCATGGTGAATAAGCAGATGTGCAATGCCAGGAGAAGAATCACACTGAAAGAGAAGGAGCAAGAGTACTTTTGTTTAGTGTTTAATAACACAATTGTACAATATCAGACTGTGGCAGCATCTAAACTGTAAAGTGAAAATACAGTATGGTATGAAGGCTGTTGGAAAGTCCCATAAAAAAAAAAGAACGTCATTACCTT
GCTATCTC/- GGGAAGGGTCCTTTTAATACATTTTAGAGTTTTCTTCATAAGGGAAGAGTTTTGTAGGAGGAAAAATGGGCGAATCAGTCTCCTGACTCTTAAATTCTGCGGGACAGAATTACAGGGCAACATTACAGTCTGTCTATCTGAGGCTGACCGCTGTTGAGTCAATCCTGCCTCTCAACACATGCTCAGTATTTACAGAAAGAATATTATAAGTGACTATAATGCTTTTTTTAATGCATTTTATTTTAATTAGCTTCTTCTTTTATGTCATTTTTAAAGCGCATGAGTTCATTTTATTTAAAATTTAGTATGTTAATAAATTATAATTTAGTTATTAATAAGAACTATTAATGTATAGTTTACTTCTCATTATTTAATGTATGGAGACTTGTAATAAATTTCTACATTTTTAACATTGATTTTAAGAATATAAACAAACATTATTATTAAATTTTAAAAGTGTAAAATACTTAAAAAAAATAAAAATAAAAAAATTATATATA - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| tpcn2dhkz1a/dhkz1a (AB/TU) | Homozygous | ♀+/- ♂+/- | 3 figures  from Kelu et al., 2017 | ||
| tpcn2dhkz1a/+ (AB/TU) | Heterozygous | Unknown | 2 figures from Kelu et al., 2017 | ||
| tpcn2dhkz1a/dhkz1a; nksaigff213aGt; zf415Tg | Complex | Fig. 1 from Kelu et al., 2018 | Fig. 1 from Kelu et al., 2018 |
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Supplemental Information
- Genotyping protocol
- None
- Rice, K.L., Chan, C.M., Kelu, J.J., Miller, A.L., Webb, S.E. (2023) A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of Membrane Contact Sites During Zebrafish Notochord Biogenesis?. Contact (Thousand Oaks (Ventura County, Calif.)). 6:2515256423121140925152564231211409
- Choi, S.S.A., Chan, H.H., Chan, C.M., Wang, X., Webb, S.E., Leung, K.W., Tsim, K.W.K., Miller, A.L. (2022) Neuromasts and Olfactory Organs of Zebrafish Larvae Represent Possible Sites of SARS-CoV-2 Pseudovirus Host Cell Entry. Journal of virology. 96(24):e0141822
- Guo, C., Webb, S.E., Chan, C.M., Miller, A.L. (2020) TPC2-mediated Ca2+ signaling is required for axon extension in caudal primary motor neurons in zebrafish embryos. Journal of Cell Science. 133(13):
- Kelu, J.J., Webb, S.E., Galione, A., Miller, A.L. (2018) TPC2-mediated Ca2+ signaling is required for the establishment of synchronized activity in developing zebrafish primary motor neurons.. Developmental Biology. 438(1):57-68
- Kelu, J.J., Webb, S.E., Parrington, J., Galione, A., Miller, A.L. (2017) Ca2+ release via two-pore channel type 2 (TPC2) is required for slow muscle cell myofibrillogenesis and myotomal patterning in intact zebrafish embryos.. Developmental Biology. 425(2):109-129
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