TALEN

TALEN1-lft1

ID
ZDB-TALEN-180417-3
Name
TALEN1-lft1
Previous Names
None
Target
Target Sequence 1
5' - TCCTGCACCTTGAAAAGA - 3'
ZFIN BLAST NCBI BLAST Ensembl
Target Sequence 2
5' - TGCGCAAAGGAGGCACGC - 3'
ZFIN BLAST NCBI BLAST Ensembl
Disclaimer
Although ZFIN verifies reagent sequence data, we recommend that you conduct independent sequence analysis before ordering any reagent.
Note
None
Genome Resources
None
Target Location
Constructs
No data available
Genomic Features
Genomic Feature Affected Genomic Regions
a145 lft1
Expression
Gene expression in Wild Types + TALEN1-lft1
No data available
Phenotype
Phenotype resulting from TALEN1-lft1
No data available
Phenotype of all Fish created by or utilizing TALEN1-lft1
Phenotype Fish Conditions Figures
heart tube bifurcated, abnormal lft1a145/a145 standard conditions Fig. 1-S1 with image from Rogers et al., 2017
margin lft1 expression spatial pattern, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis ndr2 expression increased distribution, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
heart mislocalised medially, abnormal lft1a145/a145 standard conditions Fig. 1-S1 with image from Rogers et al., 2017
blastodisc anatomical margin lft1 expression increased amount, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin ndr1 expression increased amount, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
heart mislocalised laterally, abnormal lft1a145/a145 standard conditions Fig. 1-S1 with image from Rogers et al., 2017
axis lft1 expression spatial pattern, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
heart tube myl7 expression spatial pattern, abnormal lft1a145/a145 standard conditions Fig. 1-S1 with image from Rogers et al., 2017
margin lft1 expression increased distribution, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis lft1 expression increased distribution, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin lft1 expression increased amount, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin ndr1 expression increased distribution, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis ndr2 expression increased amount, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis lft1 expression increased amount, abnormal lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
whole organism medial region lft1 expression increased amount, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm spaw expression spatial pattern, ameliorated lft1a145/a145 (AB/TL) chemical treatment by environment: SB 505124 Fig. 4 from Montague et al., 2018
notochord lft1 expression increased amount, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm right side spaw expression mislocalised, abnormal lft1a145/a145 (AB/TL) control Fig. 1 with image,  Fig. 3,  Fig. 4 from Montague et al., 2018
whole organism medial region lft1 expression increased distribution, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart jogging process quality, ameliorated lft1a145/a145 (AB/TL) chemical treatment by environment: SB 505124 Fig. 4 from Montague et al., 2018
heart jogging decreased occurrence, abnormal lft1a145/a145 (AB/TL) control Fig. 1 with image,  Fig. 4 from Montague et al., 2018
notochord lft1 expression increased distribution, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
notochord spaw expression mislocalised, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart jogging process quality, abnormal lft1a145/a145 (AB/TL) control Fig. 1 with image,  Fig. 4 from Montague et al., 2018
heart primordium right side lft2 expression mislocalised, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image,  Fig. 4 from Montague et al., 2018
heart looping decreased occurrence, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart jogging occurrence, ameliorated lft1a145/a145 (AB/TL) chemical treatment by environment: SB 505124 Fig. 4 from Montague et al., 2018
heart looping process quality, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm spaw expression increased amount, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 3 from Montague et al., 2018
lateral plate mesoderm left side spaw expression mislocalised, abnormal lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart primordium lft2 expression spatial pattern, ameliorated lft1a145/a145 (AB/TL) chemical treatment by environment: SB 505124 Fig. 4 from Montague et al., 2018
notochord lft1 expression increased distribution, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
whole organism medial region lft1 expression increased amount, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm right side spaw expression mislocalised, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image,  Fig. 3 from Montague et al., 2018
notochord lft1 expression increased amount, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
whole organism medial region lft1 expression increased distribution, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart jogging decreased occurrence, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
notochord spaw expression mislocalised, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart jogging process quality, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart looping decreased occurrence, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart primordium right side lft2 expression mislocalised, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm left side spaw expression mislocalised, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart looping process quality, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm spaw expression increased amount, abnormal dand5a204/a204; lft1a145/a145 (AB/TL) standard conditions Fig. 3 from Montague et al., 2018
margin ndr1 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
endoderm sox32 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image,  Fig. 4 with image,  Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
axis bifurcated, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1-S2 with image from Rogers et al., 2017
axis lft2 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis lft2 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis noto expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image,  Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
axis lft1 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
mesoderm noto expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
presumptive mesoderm noto expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
axis lft2 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
heart tube aplastic, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1-S1 with image from Rogers et al., 2017
caudal fin morphology, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S1 with image,  Fig. 6-S2 with image from Rogers et al., 2017
endoderm sox32 expression spatial pattern, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
whole organism morphology, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
margin lft1 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis noto expression amount, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
axis lft1 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
embryonic pattern specification decreased process quality, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1 with image from Rogers et al., 2017
presumptive endoderm sox32 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
margin lft1 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
presumptive mesoderm noto expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
margin ndr1 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
axis noto expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image,  Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
axis lft1 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
caudal fin curved dorsal, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 6-S1 with image from Rogers et al., 2017
axis ndr2 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
caudal fin decreased length, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1 with image,  Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
eye morphology, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S1 with image,  Fig. 6-S2 with image from Rogers et al., 2017
eye morphology, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
caudal fin morphology, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1 with image,  Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
heart tube myl7 expression absent, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1-S1 with image from Rogers et al., 2017
endoderm sox32 expression amount, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
whole organism necrotic, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 6 with image from Rogers et al., 2017
margin sox32 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image,  Fig. 6-S3 with image from Rogers et al., 2017
mesoderm noto expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
margin sox32 expression decreased amount, abnormal lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6-S3 with image from Rogers et al., 2017
presumptive endoderm sox32 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
margin lft2 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin lft2 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin lft1 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
whole organism Ab9-smad2 labeling increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 2 with image from Rogers et al., 2017
axis ndr2 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin lft2 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
caudal fin aplastic, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1 with image from Rogers et al., 2017
heart aplastic, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1 with image from Rogers et al., 2017
caudal fin length, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S1 with image,  Fig. 6-S2 with image from Rogers et al., 2017
presumptive endoderm sox32 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
endoderm sox17 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
margin noto expression decreased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 6-S3 with image from Rogers et al., 2017
axis noto expression spatial pattern, ameliorated lft2a146/a146; lft1a145/a145 chemical treatment by environment: SB 505124 Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
whole organism Ab9-smad2 labeling increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 2 with image,  Fig. 2-S1 with image from Rogers et al., 2017
eye aplastic, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 1 with image,  Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
margin sox32 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
presumptive mesoderm noto expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
blastodisc anatomical margin lft1 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
endoderm sox17 expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
whole organism decreased length, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
mesoderm noto expression increased amount, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image from Rogers et al., 2017
axis noto expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image,  Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
endoderm sox32 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image,  Fig. 4 with image,  Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
endoderm sox32 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3 with image,  Fig. 4 with image,  Fig. 6 with image,  Fig. 6-S3 with image from Rogers et al., 2017
whole organism morphology, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 6 with image,  Fig. 6-S1 with image from Rogers et al., 2017
margin sox32 expression spatial pattern, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image,  Fig. 6-S3 with image from Rogers et al., 2017
endoderm sox17 expression increased distribution, abnormal lft2a146/a146; lft1a145/a145 standard conditions Fig. 3-S1 with image from Rogers et al., 2017
notochord lft1 expression absent, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
lateral plate mesoderm spaw expression absent, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 3 from Montague et al., 2018
heart jogging decreased occurrence, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart primordium lft2 expression absent, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
whole organism medial region lft1 expression absent, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart jogging process quality, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart looping decreased occurrence, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
heart looping process quality, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
Kupffer's vesicle anatomical region spaw expression decreased amount, abnormal spawa205/a205; lft1a145/a145 (AB/TL) standard conditions Fig. 1 with image from Montague et al., 2018
axis curved, abnormal lft2a146/+; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
axis curved, abnormal lft2a146/+; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
whole organism morphology, abnormal lft2a146/a146; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
whole organism decreased length, abnormal lft2a146/a146; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
notochord kinked, abnormal lft2a146/a146; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
caudal fin curved dorsal, abnormal lft2a146/a146; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
eye morphology, abnormal lft2a146/a146; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
eye aplastic, abnormal lft2a146/a146; ndr1cz35/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
axis noto expression decreased amount, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
axis bifurcated, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
axis noto expression spatial pattern, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
margin noto expression decreased distribution, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
margin noto expression spatial pattern, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
margin noto expression decreased amount, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
axis noto expression decreased distribution, abnormal lft2a146/a146; ndr1cz35/cz35; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
notochord kinked, abnormal ndr2m294/+; lft2a146/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
eye morphology, abnormal ndr2m294/+; lft2a146/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
caudal fin decreased length, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
whole organism morphology, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
notochord kinked, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
whole organism decreased length, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
eye morphology, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
caudal fin morphology, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
eye aplastic, abnormal ndr2m294/+; lft2a146/a146; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
notochord kinked, abnormal ndr2m294/m294; lft2a146/+; lft1a145/a145 standard conditions Fig. 4 with image from Rogers et al., 2017
Citations
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