Cloning and genetic mapping of zebrafish BMP-2
- Lee, K.H., Marden, J.J., Thompson, M.S., MacLennan, H., Kishimoto, Y., Pratt, S.J., Schulte-Merker, S., Hammerschmidt, M., Johnson, S.L., Postlethwait, J.H., Beier, D.C., and Zon, L.I.
- Developmental genetics 23: 97-103 (Journal)
- Registered Authors
- Hammerschmidt, Matthias, Johnson, Stephen L., Kishimoto, Yasuyuki, Lee, Kyu-Ho, Postlethwait, John H., Pratt, Stephen J., Schulte-Merker, Stefan, Zon, Leonard I.
- bone morphogenetic protein; zebrafish; genetics
- MeSH Terms
- Amino Acid Sequence
- Base Sequence
- Bone Morphogenetic Protein 2
- Bone Morphogenetic Proteins/biosynthesis
- Bone Morphogenetic Proteins/genetics*
- Chromosome Mapping
- Cloning, Molecular
- DNA, Complementary/genetics
- Embryo, Nonmammalian/metabolism
- Embryo, Nonmammalian/ultrastructure
- Gene Expression Regulation, Developmental
- Molecular Sequence Data
- Mutation, Missense
- Sequence Alignment
- Sequence Homology, Amino Acid
- Transforming Growth Factor beta*
- 9770266 Full text @ Dev. Genet.
Lee, K.H., Marden, J.J., Thompson, M.S., MacLennan, H., Kishimoto, Y., Pratt, S.J., Schulte-Merker, S., Hammerschmidt, M., Johnson, S.L., Postlethwait, J.H., Beier, D.C., and Zon, L.I. (1998) Cloning and genetic mapping of zebrafish BMP-2. Developmental genetics. 23:97-103.
The BMP family of polypeptide growth factors has been shown to play diverse roles in establishing embryonic patterning and tissue fates. We report the cloning of the zebrafish homologue of BMP-2, examine its expression during embryogenesis, and find that it is localized to the distal end of the long arm of zebrafish chromosome 20. A missense mutation of the bmp2 gene has recently been shown to be responsible for the early dorsalized phenotype of the zebrafish swirl mutant [Kishimoto et al., 1997]. Given the dynamic expression of bmp2 in the developing embryo and the complex interactions of BMP signaling response in vertebrates, it is possible that other mutant phenotypes, due to altered bmp2 gene expression, will eventually map to or interact with this genetic locus.
Genes / Markers
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Engineered Foreign Genes