PUBLICATION

Mapping of Mhc class I and class II regions to different linkage groups in the zebrafish, Danio rerio

Authors
Bingulac-Popovic, J., Figueroa, F., Sato, A., Talbot, W.S., Johnson, S.L., Gates, M., Postlethwait, J.H., and Klein, J.
ID
ZDB-PUB-970722-17
Date
1997
Source
Immunogenetics   46(2): 129-134 (Journal)
Registered Authors
Figueroa, Felipe, Gates, Michael A., Johnson, Stephen L., Klein, Jan, Postlethwait, John H., Sato, Atsushi, Talbot, William S.
Keywords
none
MeSH Terms
  • Animals
  • Chromosome Mapping*
  • Genetic Linkage
  • Histocompatibility Antigens Class I/genetics*
  • Histocompatibility Antigens Class II/genetics*
  • Zebrafish/genetics*
PubMed
9162099 Full text @ Immunogenetics
Abstract
The mammalian major histocompatibility complex (Mhc) consists of three closely linked regions, I, II, and III, occupying a single chromosomal segment. The class I loci in region I and the class II loci in region II are related in their structure, function, and evolution. Region III, which is intercalated between regions I and II, contains loci unrelated to the class I and II loci, and to one another. There are indications that a similar Mhc organization exists in birds and amphibians. Here, we demonstrate that in the zebrafish (Danio rerio), a representative of the teleost fishes, the class II loci are divided between two linkage groups which are distinct from the linkage group containing the class I loci. The beta2- microglobulin-encoding gene is loosely linked to one of the class II loci. The gene coding for complement factor B, which is one of the region III genes in mammals, is linked neither to the class I nor to the class II loci in the zebrafish. These results, combined with preliminary data suggesting that the class I and class II regions in another order of teleost fish are also in different linkage groups, indicate that close linkage of the two regions is not necessary either for regulation of expression or for co-evolution of the class I and class II loci. They also raise the question of whether linkage of the class I and class II loci in tetrapods is a primitive or derived character.
Genes / Markers
Figures
Expression
Phenotype
Mutation and Transgenics
Human Disease / Model Data
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping
Errata and Notes