PUBLICATION
Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish
- Authors
- Pallucchi, I., Bertuzzi, M., Madrid, D., Fontanel, P., Higashijima, S.I., El Manira, A.
- ID
- ZDB-PUB-231103-9
- Date
- 2023
- Source
- Nature Neuroscience 27(1): 78-89 (Journal)
- Registered Authors
- Higashijima, Shin-ichi
- Keywords
- none
- Datasets
- GEO:GSE243993
- MeSH Terms
-
- Animals
- Interneurons/physiology
- Locomotion*/genetics
- Motor Neurons/physiology
- Spinal Cord/physiology
- Zebrafish*/physiology
- PubMed
- 37919423 Full text @ Nat. Neurosci.
Citation
Pallucchi, I., Bertuzzi, M., Madrid, D., Fontanel, P., Higashijima, S.I., El Manira, A. (2023) Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish. Nature Neuroscience. 27(1):78-89.
Abstract
The flexibility of motor actions is ingrained in the diversity of neurons and how they are organized into functional circuit modules, yet our knowledge of the molecular underpinning of motor circuit modularity remains limited. Here we use adult zebrafish to link the molecular diversity of motoneurons (MNs) and the rhythm-generating V2a interneurons (INs) with the modular circuit organization that is responsible for changes in locomotor speed. We show that the molecular diversity of MNs and V2a INs reflects their functional segregation into slow, intermediate or fast subtypes. Furthermore, we reveal shared molecular signatures between V2a INs and MNs of the three speed circuit modules. Overall, by characterizing how the molecular diversity of MNs and V2a INs relates to their function, connectivity and behavior, our study provides important insights not only into the molecular mechanisms for neuronal and circuit diversity for locomotor flexibility but also for charting circuits for motor actions in general.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping