PUBLICATION
Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases
- Authors
- Dai, Y.T., Zhang, F., Fang, H., Li, J.F., Lu, G., Jiang, L., Chen, B., Mao, D.D., Liu, Y.F., Wang, J., Peng, L.J., Feng, C., Chen, H.F., Mu, J.X., Zhang, Q.L., Wang, H., Ariffin, H., Moy, T.A., Wang, J.H., Lou, Y.J., Chen, S.N., Wang, Q., Liu, H., Shan, Z., Matsumura, I., Miyazaki, Y., Yasuda, T., Dou, L.P., Yan, X.J., Yan, J.S., Yeoh, A.E., Wu, D.P., Kiyoi, H., Hayakawa, F., Jin, J., Wang, S.Y., Sun, X.J., Mi, J.Q., Chen, Z., Huang, J.Y., Chen, S.J.
- ID
- ZDB-PUB-220411-2
- Date
- 2022
- Source
- Proceedings of the National Academy of Sciences of the United States of America 119: e2120787119 (Journal)
- Registered Authors
- Chen, Zhu, Sun, Xiao-Jian, Zhang, Fan
- Keywords
- RNA sequencing, T cell differentiation stages, T-ALL, molecular subtyping, mutation
- MeSH Terms
-
- Child
- Humans
- Mutation
- Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics
- Transcriptome*
- PubMed
- 35385357 Full text @ Proc. Natl. Acad. Sci. USA
Citation
Dai, Y.T., Zhang, F., Fang, H., Li, J.F., Lu, G., Jiang, L., Chen, B., Mao, D.D., Liu, Y.F., Wang, J., Peng, L.J., Feng, C., Chen, H.F., Mu, J.X., Zhang, Q.L., Wang, H., Ariffin, H., Moy, T.A., Wang, J.H., Lou, Y.J., Chen, S.N., Wang, Q., Liu, H., Shan, Z., Matsumura, I., Miyazaki, Y., Yasuda, T., Dou, L.P., Yan, X.J., Yan, J.S., Yeoh, A.E., Wu, D.P., Kiyoi, H., Hayakawa, F., Jin, J., Wang, S.Y., Sun, X.J., Mi, J.Q., Chen, Z., Huang, J.Y., Chen, S.J. (2022) Transcriptome-wide subtyping of pediatric and adult T cell acute lymphoblastic leukemia in an international study of 707 cases. Proceedings of the National Academy of Sciences of the United States of America. 119:e2120787119.
Abstract
SignificanceWe provide transcriptomic insights into differences between pediatric and adult T cell acute lymphoblastic leukemia (T-ALL) patients through an international collaborative effort integrating RNA-sequencing data of 707 patients. Ten subtypes were identified, each characterized by distinct gene mutation profiles and dysregulated expression signatures of leukemogenic factors, and associated with T cell development stages. Adult T-ALL tends to have characteristics of early T cell precursor ALL, mostly corresponding to the mixed phenotype acute leukemia, whereas pediatric T-ALL shows a wide spectrum of aberrant molecular features, from early T cell precursor to mature T cell compartments. Our findings have important implications for disease mechanism of T-ALL that differs between pediatric and adult patients, facilitating further refined targeted therapy.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping