ZFIN ID: ZDB-PERS-180319-10
Sun, Xiao-Jian
Email: xjsun@sibs.ac.cn
URL: https://www.researchgate.net/profile/Xiao-Jian-Sun
Affiliation: Xiao-Jian Sun Lab
Address: 197 Ruijin Road II, Building 11 Room 807, Shanghai, 200025
Country: China
Phone: +86-21-64370045-610807
Fax: +86-21-64743206
ORCID ID: 0000-0001-8826-4614

Xiao-Jian Sun conducted his Ph.D. studies with Dr. Zhu Chen at the Shanghai Institute of Hematology and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and gained postdoctoral training with Dr. Robert G. Roeder at the Rockefeller University. He had also spent over three months to work with Drs. Thomas A. Look and Leonard I. Zon as a visiting student at Harvard Medical School to learn zebrafish embryonic and hematopoietic development. Xiao-Jian Sun currently serves as a Principal Investigator at the Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine. His research interest is the transcriptional and epigenetic regulation of hematopoietic stem cell and leukemia, and his scientific contributions include: (i) identification of the leukemogenic transcription factor complex AETFC; (ii) identification of the human histone H3K36 methyltransferase SETD2; and (iii) establishment of a developmental expression profile of hematopoietic genes in zebrafish kidney marrow.

Zhang, F., Zeng, Q.Y., Xu, H., Xu, A.N., Liu, D.J., Li, N.Z., Chen, Y., Jin, Y., Xu, C.H., Feng, C.Z., Zhang, Y.L., Liu, D., Liu, N., Xie, Y.Y., Yu, S.H., Yuan, H., Xue, K., Shi, J.Y., Liu, T.X., Xu, P.F., Zhao, W.L., Zhou, Y., Wang, L., Huang, Q.H., Chen, Z., Chen, S.J., Zhou, X.L., Sun, X.J. (2021) Selective and competitive functions of the AAR and UPR pathways in stress-induced angiogenesis. Cell discovery. 7:98
Huang, Y., Yu, S.H., Zhen, W.X., Cheng, T., Wang, D., Lin, J.B., Wu, Y.H., Wang, Y.F., Chen, Y., Shu, L.P., Wang, Y., Sun, X.J., Zhou, Y., Yang, F., Hsu, C.H., Xu, P.F. (2021) Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 11:6891-6904
Liu, D.J., Zhang, F., Chen, Y., Jin, Y., Zhang, Y.L., Chen, S.B., Xie, Y.Y., Huang, Q.H., Zhao, W.L., Wang, L., Xu, P.F., Chen, Z., Chen, S.J., Li, B., Zhang, A., Sun, X.J. (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell discovery. 6:72
Xie, Y., Gao, L., Xu, C., Chu, L., Gao, L., Wu, R., Liu, Y., Liu, T., Sun, X.J., Ren, R., Tang, J., Zheng, Y., Zhou, Y., Shen, S. (2019) ARHGEF12 regulates erythropoiesis and is involved in erythroid regeneration after chemotherapy in acute lymphoblastic leukemia patients. Haematologica. 105(4):925-936
Xu, P.F., Zhu, K.Y., Jin, Y., Chen, Y., Sun, X.J., Deng, M., Chen, S.J., Chen, Z., and Liu, T.X. (2010) Setdb2 restricts dorsal organizer territory and regulates left-right asymmetry through suppressing fgf8 activity. Proceedings of the National Academy of Sciences of the United States of America. 107(6):2521-2526
Sun, X.J., Xu, P.F., Zhou, T., Hu, M., Fu, C.T., Zhang, Y., Jin, Y., Chen, Y., Chen, S.J., Huang, Q.H., Liu, T.X., and Chen, Z. (2008) Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS One. 3(1):e1499
Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245

1. Zhang,M.M., Liu,N., Zhang,Y.L., Rong,B., Wang,X.L., Xu,C.H., Xie,Y.Y., Shen,S., Zhu,J., Nimer,S.D., Chen,Z., Chen,S.J., Roeder,R.G., Lan,F., Wang,L., Huang,Q.H., Sun,X.J. (2019) Destabilization of AETFC through C/EBPalpha-mediated repression of LYL1 contributes to t(8;21) leukemic cell differentiation. Leukemia, in press.
2. Liu,N., Song,J., Xie,Y., Wang,X.L., Rong,B., Man,N., Zhang,M.M., Zhang,Q., Gao,F.F., Du,M.R., Zhang,Y., Shen,J., Xu,C.H., Hu,C.L., Wu,J.C., Liu,P., Zhang,Y.L., Xie,Y.Y., Liu,P., Huang,J., Huang,Q.H., Lan,F., Shen,S., Nimer,S.D., Chen,Z., Chen,S.J., Roeder,R.G., Wang,L., Sun,X.J. (2019) Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis. Proc. Natl. Acad. Sci. U. S. A., 116(3):890-899.
3. Zhang,Y.L., Sun,J.W., Xie,Y.Y., Zhou,Y., Liu,P., Song,J.C., Xu,C.H., Wang,L., Liu,D., Xu,A.N., Chen,Z., Chen,S.J., Sun,X.J. (co-corresponding author), Huang,Q.H. (2018) Setd2 deficiency impairs hematopoietic stem cell self-renewal and causes malignant transformation. Cell Research, 28(4):476-490.
4. Man,N., Tan,Y., Sun,X.J., Liu,F., Cheng,G., Greenblatt,S.M., Martinez,C., Karl,D.L., Ando,K., Sun,M., Hou,D., Chen,B., Xu,M., Yang,F.C., Chen,Z., Chen,S., Nimer,S.D., Wang,L. (2017) Caspase-3 controls AML1-ETO-driven leukemogenesis via autophagy modulation in a ULK1-dependent manner. Blood, 129(20):2782-2792.
5. Kobayashi,M., Chen,S., Bai,Y., Yao,C., Gao,R., Sun,X.J., Mu,C., Twiggs,T.A., Yu,Z.H., Boswell,H.S., Yoder,M.C., Kapur,R., Mulloy,J.C., Zhang,Z.Y., Liu,Y. (2017) Phosphatase PRL2 promotes AML1-ETO-induced acute myeloid leukemia. Leukemia, 31(6):1453-1457.
6. Liu,D., Huang,Q.H., Sun,X.J. (2017). Unbiased evidence for single E. coli colony containing diverse plasmids. PubRaw Science, 1(7):1-5.
7. Yang,L.S., Zhang,X.J., Xie,Y.Y., Sun,X.J., Zhao,R., Huang,Q.H. (2016) SUMOylated MAFB promotes colorectal cancer tumorigenesis. Oncotarget, 7(50):83488-83501.
8. Man,N., Sun,X.J. (co-first author), Tan,Y., Cao,M.G., Liu,F., Cheng,G., Hatlen,M., Xu,H., Shah,R., Chastain,N., Liu,N., Huang,G., Zhou,Y., Sheng,M., Song,J., Yang,F.C., Benezra,R., Nimer,S.D., Wang,L. (2016) Differential role of Id1 in MLL-AF9-driven leukemia based on cell of origin. Blood, 127(19):2322-2326.
9. Wang,L., Man,N., Sun,X.J., Tan,Y., Cao,M., Liu,F., Hatlen,M., Xu,H., Huang,G., Mattlin,M., Mehta,A., Rampersaud,E., Benezra,R., Nimer,S. (2015) Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood, 126(5):640-650.
10. Sun,X.J., Man,N., Tan,Y., Nimer,S., Wang,L. (2015) The role of histone acetyltransferases in normal and malignant hematopoiesis. Front. Oncol., 5:108.
11. Zhang,Y., Xie,S., Zhou,Y., Xie,Y., Liu,P., Sun,M., Xiao,H., Jin,Y., Sun,X., Chen,Z., Huang,Q., Chen,S. (2014) H3K36 Histone methyltransferase Setd2 is required for murine embryonic stem cell differentiation toward endoderm. Cell Rep., 8(6):1989-2002.
12. Sun,X.J., Wang,Z., Wang,L., Jiang,Y., Kost,N., Soong,T.D., Chen,W.Y., Tang,Z., Nakadai,T., Elemento,O., Fischle,W., Melnick,A., Patel,D.J., Nimer,S.D., and Roeder,R.G. (2013). A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis. Nature, 500(7460):93-97.
13. Tang,Z., Chen,W.Y., Shimada,M., Nguyen,U.T., Kim,J., Sun,X.J., Sengoku,T., McGinty,R.K., Fernandez,J.P., Muir,T.W., and Roeder,R.G. (2013). SET1 and p300 synergy, through coupled histone modifications, in transcriptional activation by p53. Cell, 154(2):297-310.
14. Wang,L., Gural,A., Sun,X.J., Zhao,X., Perna,F., Huang,G., Hatlen,M.A., Vu,L., Liu,F., Xu,H., Asai,T., Xu,H., DeBlasio,T., Menendez,S., Voza,F., Jiang,Y., Cole,P.A., Zhang,J., Melnick,A., Roeder,R.G., and Nimer,S.D. (2011). The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science, 333(6043):765-769.
15. Park,J.H., Sun,X.J., and Roeder,R.G. (2010). The SANT domain of p400 ATPase represses acetyltransferase activity and coactivator function of TIP60 in basal p21 gene expression. Mol. Cell Biol., 30(11):2750-2761.
16. Hu,M., Sun,X.J. (co-first author), Zhang,Y.L., Kuang,Y., Hu,C.Q., Wu,W.L., Shen,S.H., Du,T.T., Li,H., He,F., Xiao,H.S., Wang,Z.G., Liu,T.X., Lu,H., Huang,Q.H., Chen,S.J., and Chen,Z. (2010). Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling. Proc. Natl. Acad. Sci. U. S. A., 107(7):2956-2961.
17. Wang,L., Zhao,W.L., Yan,J.S., Liu,P., Sun,H.P., Zhou,G.B., Weng,Z.Y., Wu,W.L., Weng,X.Q., Sun,X.J., Chen,Z., Sun,H.D., and Chen,S.J. (2007). Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death. Differ., 14(2):306-317.
18. Sun,X.J., Wei,J., Wu,X.Y., Hu,M., Wang,L., Wang,H.H., Zhang,Q.H., Chen,S.J., Huang,Q.H., and Chen,Z. (2005). Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J. Biol. Chem., 280(42):35261-35271.