ZFIN ID: ZDB-PUB-210303-5
Zebrafish as an animal model for biomedical research
Choi, T.Y., Choi, T.I., Lee, Y.R., Choe, S.K., Kim, C.H.
Date: 2021
Source: Experimental & molecular medicine   53(3): 310-317 (Review)
Registered Authors: Choe, Seong-Kyu
Keywords: none
MeSH Terms: none
PubMed: 33649498 Full text @ Exp. Mol. Med.
Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine because they provide new diagnostic and therapeutic solutions. This review focuses on zebrafish disease models for biomedical research, mainly in developmental disorders, mental disorders, and metabolic diseases.