PUBLICATION
Zebrafish as an animal model for biomedical research
- Authors
- Choi, T.Y., Choi, T.I., Lee, Y.R., Choe, S.K., Kim, C.H.
- ID
- ZDB-PUB-210303-5
- Date
- 2021
- Source
- Experimental & molecular medicine 53(3): 310-317 (Review)
- Registered Authors
- Choe, Seong-Kyu
- Keywords
- none
- MeSH Terms
-
- Animals
- Biomedical Research*
- Developmental Disabilities/pathology*
- Developmental Disabilities/therapy
- Disease Models, Animal*
- Humans
- Mental Disorders/pathology*
- Mental Disorders/therapy
- Metabolic Diseases/pathology*
- Metabolic Diseases/therapy
- Zebrafish
- PubMed
- 33649498 Full text @ Exp. Mol. Med.
Citation
Choi, T.Y., Choi, T.I., Lee, Y.R., Choe, S.K., Kim, C.H. (2021) Zebrafish as an animal model for biomedical research. Experimental & molecular medicine. 53(3):310-317.
Abstract
Zebrafish have several advantages compared to other vertebrate models used in modeling human diseases, particularly for large-scale genetic mutant and therapeutic compound screenings, and other biomedical research applications. With the impactful developments of CRISPR and next-generation sequencing technology, disease modeling in zebrafish is accelerating the understanding of the molecular mechanisms of human genetic diseases. These efforts are fundamental for the future of precision medicine because they provide new diagnostic and therapeutic solutions. This review focuses on zebrafish disease models for biomedical research, mainly in developmental disorders, mental disorders, and metabolic diseases.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping