ZFIN ID: ZDB-PUB-210203-7
Seizures are a druggable mechanistic link between TBI and subsequent tauopathy
Alyenbaawi, H., Kanyo, R., Locskai, L.F., Kamali-Jamil, R., DuVal, M.G., Bai, Q., Wille, H., Burton, E.A., Allison, W.T.
Date: 2021
Source: eLIFE   10: (Journal)
Registered Authors: Allison, Ted, Burton, Edward A., Duval, Michèle
Keywords: anti-epileptics, epilepsy, neuroscience, neurotrauma, post-traumatic seizures, tauopathy, traumatic brain injury, zebrafish
MeSH Terms: none
PubMed: 33527898 Full text @ Elife
Traumatic brain injury (TBI) is a prominent risk factor for dementias including tauopathies like chronic traumatic encephalopathy (CTE). The mechanisms that promote prion-like spreading of Tau aggregates after TBI are not fully understood, in part due to lack of tractable animal models. Here, we test the putative role of seizures in promoting the spread of tauopathy. We introduce 'tauopathy reporter' zebrafish expressing a genetically encoded fluorescent Tau biosensor that reliably reports accumulation of human Tau species when seeded via intraventricular brain injections. Subjecting zebrafish larvae to a novel TBI paradigm produced various TBI features including cell death, post-traumatic seizures, and Tau inclusions. Bath application of dynamin inhibitors or anticonvulsant drugs rescued TBI-induced tauopathy and cell death. These data suggest a role for seizure activity in the prion-like seeding and spreading of tauopathy following TBI. Further work is warranted regarding anti-convulsants that dampen post-traumatic seizures as a route to moderating subsequent tauopathy.