ZFIN ID: ZDB-PUB-110110-13
Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain
Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J.
Date: 2011
Source: Proceedings of the National Academy of Sciences of the United States of America   108(3): 1170-1175 (Journal)
Registered Authors: Fetcho, Joseph R., Higashijima, Shin-ichi
Keywords: development, locomotion, neuronal circuit, Mauthner neuron
MeSH Terms:
  • Animals
  • Animals, Genetically Modified
  • Body Patterning/physiology*
  • Brain Mapping/methods*
  • Electrophysiology
  • Escape Reaction/physiology*
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Interneurons/metabolism
  • Larva/anatomy & histology
  • Larva/physiology
  • Nerve Net*
  • Patch-Clamp Techniques
  • Psychomotor Performance/physiology
  • Rhombencephalon/anatomy & histology
  • Rhombencephalon/physiology*
  • Zebrafish/anatomy & histology
  • Zebrafish/physiology*
PubMed: 21199937 Full text @ Proc. Natl. Acad. Sci. USA
The hindbrain of larval zebrafish contains a relatively simple ground plan in which the neurons throughout it are arranged into stripes that represent broad neuronal classes that differ in transmitter identity, morphology, and transcription factor expression. Within the stripes, neurons are stacked continuously according to age as well as structural and functional properties, such as axonal extent, input resistance, and the speed at which they are recruited during movements. Here we address the question of how particular networks among the many different sensory-motor networks in hindbrain arise from such an orderly plan. We use a combination of transgenic lines and pairwise patch recording to identify excitatory and inhibitory interneurons in the hindbrain network for escape behaviors initiated by the Mauthner cell. We map this network onto the ground plan to show that an individual hindbrain network is built by drawing components in predictable ways from the underlying broad patterning of cell types stacked within stripes according to their age and structural and functional properties. Many different specialized hindbrain networks may arise similarly from a simple early patterning.