ZFIN is now using GRCz12tu for Genomic Data
Gene
cacnb1
- ID
- ZDB-GENE-040718-399
- Name
- calcium channel, voltage-dependent, beta 1 subunit
- Symbol
- cacnb1 Nomenclature History
- Previous Names
-
- dihydropyridine receptor b1 (1)
- red
- relaxed
- zgc:91982
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Enables voltage-gated calcium channel activity. Acts upstream of or within muscle contraction and voltage-gated calcium channel complex assembly. Part of voltage-gated calcium channel complex. Is expressed in several structures, including basal plate midbrain region; hatching gland; musculature system; nervous system; and polster. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:91982 (22 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ir1092 | unknown | Unknown | Unknown | not specified | |
| la015086Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| mi90 | Allele with one point mutation | Unknown | Premature Stop | not specified | |
| sa8705 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33120 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ts25 | Allele with one point mutation | Exon 13 | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR046937 | Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain |
| Family | IPR000584 | Voltage-dependent calcium channel, L-type, beta subunit |
| Family | IPR005443 | Voltage-dependent calcium channel, L-type, beta-1 subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Guanylate kinase/L-type calcium channel beta subunit | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily | Voltage-dependent calcium channel, L-type, beta-1 subunit | Voltage-dependent calcium channel, L-type, beta subunit | Voltage-dependent L-type calcium channel subunit beta-1-4, N-terminal A domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BAY4 | InterPro | 645 | |||||||
| UniProtKB:A0A8M2BBA6 | InterPro | 642 | |||||||
| UniProtKB:A0A8M3B0T0 | InterPro | 606 | |||||||
| UniProtKB:A0A8M3AQC9 | InterPro | 597 | |||||||
| UniProtKB:Q2Q551 | InterPro | 603 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacnb1-201
(1)
|
Ensembl | 1,563 nt | ||
| mRNA |
cacnb1-202
(1)
|
Ensembl | 2,043 nt | ||
| mRNA |
cacnb1-203
(1)
|
Ensembl | 1,670 nt | ||
| mRNA |
cacnb1-205
(1)
|
Ensembl | 1,554 nt | ||
| ncRNA |
cacnb1-004
(1)
|
Ensembl | 690 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-10J9 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-81L17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:91982 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002652 (1) | 1680 nt | ||
| Genomic | GenBank:CR388097 (1) | 195927 nt | ||
| Polypeptide | UniProtKB:A0A8M2BAY4 (1) | 645 aa |
- Nayak, P.K., Subramanian, A., Schilling, T.F. (2025) Transcriptome profiling of tendon fibroblasts at the onset of embryonic muscle contraction reveals novel force-responsive genes. eLIFE. 14:
- Cai, W., Wang, Y., Luo, Y., Gao, L., Zhang, J., Jiang, Z., Fan, X., Li, F., Xie, Y., Wu, X., Li, Y., Yuan, W. (2023) asb5a/asb5b Double Knockout Affects Zebrafish Cardiac Contractile Function. International Journal of Molecular Sciences. 24(22):
- Dayal, A., Perni, S., Franzini-Armstrong, C., Beam, K.G., Grabner, M. (2022) The distal C terminus of the dihydropyridine receptor β1a subunit is essential for tetrad formation in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 119:e2201136119
- Linsley, J.W., Shah, K., Castello, N., Chan, M., Haddad, D., Doric, Z., Wang, S., Leks, W., Mancini, J., Oza, V., Javaherian, A., Nakamura, K., Kokel, D., Finkbeiner, S. (2021) Genetically encoded cell-death indicators (GEDI) to detect an early irreversible commitment to neurodegeneration. Nature communications. 12:5284
- Wen, H., Eckenstein, K., Weihrauch, V., Stigloher, C., Brehm, P. (2020) Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 117(42):26429-26437
- Dayal, A., Ng, S.F.J., Grabner, M. (2019) Ca2+-activated Cl- channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration. Nature communications. 10:115
- Pichler, P., Lagnado, L. (2019) Motor Behavior Selectively Inhibits Hair Cells Activated by Forward Motion in the Lateral Line of Zebrafish. Current biology : CB. 30(1):150-157.e3
- Shimazaki, T., Tanimoto, M., Oda, Y., Higashijima, S.I. (2018) Behavioral role of the reciprocal inhibition between a pair of Mauthner cells during fast escapes in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(7):1182-1194
- Subramanian, A., Kanzaki, L.F., Galloway, J.L., Schilling, T.F. (2018) Mechanical force regulates tendon extracellular matrix organization and tenocyte morphogenesis through TGFbeta signaling. eLIFE. 7:
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
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