PUBLICATION
Melanoma biology and the promise of zebrafish
- Authors
- Ceol, C.J., Houvras, Y., White, R.M., and Zon, L.I.
- ID
- ZDB-PUB-090116-2
- Date
- 2008
- Source
- Zebrafish 5(4): 247-255 (Review)
- Registered Authors
- Ceol, Craig, Houvras, Yariv, White, Richard M., Zon, Leonard I.
- Keywords
- none
- MeSH Terms
-
- Animals
- Melanocytes/metabolism
- Melanoma/metabolism*
- Zebrafish/metabolism*
- Zebrafish Proteins/genetics
- Zebrafish Proteins/metabolism
- PubMed
- 19133823 Full text @ Zebrafish
Citation
Ceol, C.J., Houvras, Y., White, R.M., and Zon, L.I. (2008) Melanoma biology and the promise of zebrafish. Zebrafish. 5(4):247-255.
Abstract
Advantageous organismal and technical attributes of the zebrafish are being increasingly applied to study cancer biology. Along with other tumor models, zebrafish that develop melanomas have been generated. In both genetics and phenotype, zebrafish melanomas are strikingly similar to their human counterparts. For this reason, studies in the zebrafish are poised to make significant contributions to melanoma biology. In this review, we summarize important features of human melanoma and discuss how the zebrafish can be used to address many questions that remain unanswered about this devastating disease.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping