ZFIN ID: ZDB-PERS-060712-20
Houvras, Yariv
Email: yah9014@med.cornell.edu
URL:
Affiliation: Yariv Houvras Laboratory
Address: Howard Hughes Medical Institute Children's Hospital Boston Division of Hematology/Oncology 300 Longwood Avenue, Karp 8 Boston, MA 02115 USA
Country: United States
Phone: 212-746-9418
Fax: 212-746-8572
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Neelamraju, Y., Gjini, E., Chhangawala, S., Fan, H., He, S., Jing, C.B., Nguyen, A.T., Prajapati, S., Sheridan, C., Houvras, Y., Melnick, A., Look, A.T., Garrett-Bakelman, F.E. (2023) Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome. Frontiers in hematology. 2:
Ellis, J.L., Evason, K.J., Zhang, C., Fourman, M.N., Liu, J., Ninov, N., Delous, M., Vanhollebeke, B., Fiddes, I., Otis, J.P., Houvras, Y., Farber, S.A., Xu, X., Lin, X., Stainier, D.Y.R., Yin, C. (2022) A missense mutation in the proprotein convertase gene furinb causes hepatic cystogenesis during liver development in zebrafish. Hepatology communications. 6(11):3083-3097
Maskin, C.R., Raman, R., Houvras, Y. (2022) PPP6C, a serine-threonine phosphatase, regulates melanocyte differentiation and contributes to melanoma tumorigenesis through modulation of MITF activity. Scientific Reports. 12:5573
DiNapoli, S.E., Martinez-McFaline, R., Shen, H., Doane, A.S., Perez, A.R., Verma, A., Simon, A., Nelson, I., Balgobin, C.A., Bourque, C.T., Yao, J., Raman, R., Béguelin, W., Zippin, J.H., Elemento, O., Melnick, A.M., Houvras, Y. (2022) Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms. Frontiers in cell and developmental biology. 10:814216
Weeks, O., Bossé, G.D., Oderberg, I.M., Akle, S., Houvras, Y., Wrighton, P.J., LaBella, K., Iversen, I., Tavakoli, S., Adatto, I., Schwartz, A., Kloosterman, D., Tsomides, A., Charness, M.E., Peterson, R.T., Steinhauser, M.L., Fazeli, P.K., Goessling, W. (2020) Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. The Journal of Clinical Investigation. 130(5):2252-2269
Salhi, A., Jordan, A.C., Bochaca, I.I., Izsak, A., Darvishian, F., Houvras, Y., Giles, K.M., Osman, I. (2020) Oxidative phosphorylation promotes primary melanoma invasion. The American journal of pathology. 190(5):1108-1117
DiNapoli, S.E., Martinez-McFaline, R., Gribbin, C.K., Wrighton, P.J., Balgobin, C.A., Nelson, I., Leonard, A., Maskin, C.R., Shwartz, A., Quenzer, E.D., Mailhiot, D., Kao, C., McConnell, S.C., de Jong, J.L.O., Goessling, W., Houvras, Y. (2020) Synthetic CRISPR/Cas9 reagents facilitate genome editing and homology directed repair. Nucleic acids research. 48(7):e38
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Cox, A.G., Tsomides, A., Yimlamai, D., Hwang, K.L., Miesfeld, J., Galli, G.G., Fowl, B.H., Fort, M., Ma, K.Y., Sullivan, M.R., Hosios, A.M., Snay, E., Yuan, M., Brown, K.K., Lien, E.C., Chhangawala, S., Steinhauser, M.L., Asara, J.M., Houvras, Y., Link, B., Vander Heiden, M.G., Camargo, F.D., Goessling, W. (2018) Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. The EMBO journal. 37(22):
Venkatesan, A.M., Vyas, R., Gramann, A.K., Dresser, K., Gujja, S., Bhatnagar, S., Chhangawala, S., Gomes, C.B.F., Xi, H.S., Lian, C.G., Houvras, Y., Edwards, Y.J.K., Deng, A., Green, M., Ceol, C.J. (2017) Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. The Journal of Clinical Investigation. 128(1):294-308
Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M., Ceol, C.J. (2017) Identification and characterization of T reg-like cells in zebrafish. The Journal of experimental medicine. 214(12):3519-3530
Anelli, V., Villefranc, J.A., Chhangawala, S., Martinez-McFaline, R., Riva, E., Nguyen, A., Verma, A., Bareja, R., Chen, Z., Scognamiglio, T., Elemento, O., Houvras, Y. (2017) Oncogenic BRAF disrupts thyroid morphogenesis and function via Twist expression. eLIFE. 6
Cox, A.G., Tsomides, A., Kim, A.J., Saunders, D., Hwang, K.L., Evason, K.J., Heidel, J., Brown, K.K., Yuan, M., Lien, E.C., Lee, B.C., Nissim, S., Dickinson, B., Chhangawala, S., Chang, C.J., Asara, J.M., Houvras, Y., Gladyshev, V.N., Goessling, W. (2016) Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 113(38):E5562-71
Cox, A.G., Hwang, K.L., Brown, K.K., Evason, K.J., Beltz, S., Tsomides, A., O'Connor, K., Galli, G.G., Yimlamai, D., Chhangawala, S., Yuan, M., Lien, E.C., Wucherpfennig, J., Nissim, S., Minami, A., Cohen, D.E., Camargo, F.D., Asara, J.M., Houvras, Y., Stainier, D.Y., Goessling, W. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nature cell biology. 18(8):886-96
Tang, Q., Moore, J.C., Ignatius, M.S., Tenente, I.M., Hayes, M.N., Garcia, E.G., Torres Yordán, N., Bourque, C., He, S., Blackburn, J.S., Look, A.T., Houvras, Y., Langenau, D.M. (2016) Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish. Nature communications. 7:10358
Ceol, C.J., Houvras, Y. (2016) Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery. Advances in experimental medicine and biology. 916:3-19
Boysen, G., Barbieri, C.E., Prandi, D., Blattner, M., Chae, S.S., Dahija, A., Nataraj, S., Huang, D., Marotz, C., Xu, L., Huang, J., Lecca, P., Chhangawala, S., Liu, D., Zhou, P., Sboner, A., de Bono, J.S., Demichelis, F., Houvras, Y., Rubin, M.A. (2015) SPOP mutation leads to genomic instability in prostate cancer. eLIFE. 4
Salhi, A., Farhadian, J.A., Giles, K.M., Vega-Saenz de Miera, E., Silva, I.P., Bourque, C., Yeh, K., Chhangawala, S., Wang, J., Ye, F., Zhang, D.Y., Hernando-Monge, E., Houvras, Y., Osman, I. (2015) RSK1 Activation Promotes Invasion in Nodular Melanoma. The American journal of pathology. 185(3):704-16
Tang, Q., Abdelfattah, N.S., Blackburn, J.S., Moore, J.C., Martinez, S.A., Moore, F.E., Lobbardi, R., Tenente, I.M., Ignatius, M.S., Berman, J.N., Liwski, R.S., Houvras, Y., Langenau, D.M. (2014) Optimized cell transplantation using adult rag2 mutant zebrafish. Nature Methods. 11(8):821-4
Iyengar, S., Houvras, Y., and Ceol, C.J. (2012) Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model. Journal of visualized experiments : JoVE. (69):e50086
Bourque, C., and Houvras, Y. (2011) Hooked on Zebrafish: Insights into Development and Cancer of Endocrine Tissues. Endocrine-related cancer. 18(5):R149-64
Ceol, C.J., Houvras, Y., Jane-Valbuena, J., Bilodeau, S., Orlando, D.A., Battisti, V., Fritsch, L., Lin, W.M., Hollmann, T.J., Ferré, F., Bourque, C., Burke, C.J., Turner, L., Uong, A., Johnson, L.A., Beroukhim, R., Mermel, C.H., Loda, M., Ait-Si-Ali, S., Garraway, L.A., Young, R.A., and Zon, L.I. (2011) The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471(7339):513-517
Ceol, C.J., Houvras, Y., White, R.M., and Zon, L.I. (2008) Melanoma biology and the promise of zebrafish. Zebrafish. 5(4):247-255
Sessa, A.K., White, R., Houvras, Y., Burke, C., Pugach, E., Baker, B., Gilbert, R., Look, A.T., and Zon, L.I. (2008) The effect of a depth gradient on the mating behavior, oviposition site preference, and embryo production in the zebrafish, Danio rerio. Zebrafish. 5(4):335-339

NON-ZEBRAFISH PUBLICATIONS