ZFIN ID: ZDB-PERS-060712-9
Ceol, Craig
Email: Craig.Ceol@umassmed.edu
Affiliation: Ceol Lab
Address: University of Massachusetts Medical School Albert Sherman Center AS6-1041 368 Plantation Street Worcester, MA 01605 USA
Country: United States
Phone: 508-856-5509


Frantz, W.T., Iyengar, S., Neiswender, J., Cousineau, A., Maehr, R., Ceol, C.J. (2023) Pigment cell progenitor heterogeneity and reiteration of developmental signaling underlie melanocyte regeneration in zebrafish. eLIFE. 12:
Darp, R., Vittoria, M.A., Ganem, N.J., Ceol, C.J. (2022) Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis. Nature communications. 13:4109
Wilcock, D.J., Badrock, A.P., Wong, C.W., Owen, R., Guerin, M., Southam, A.D., Johnston, H., Telfer, B.A., Fullwood, P., Watson, J., Ferguson, H., Ferguson, J., Lloyd, G.R., Jankevics, A., Dunn, W.B., Wellbrock, C., Lorigan, P., Ceol, C., Francavilla, C., Smith, M.P., Hurlstone, A.F.L. (2022) Oxidative stress from DGAT1 oncoprotein inhibition in melanoma suppresses tumor growth when ROS defenses are also breached. Cell Reports. 39:110995
Frantz, W.T., Ceol, C.J. (2022) Research Techniques Made Simple: Zebrafish Models for Human Dermatologic Disease. The Journal of investigative dermatology. 142:499-506.e1
Patton, E.E., Mueller, K.L., Adams, D.J., Anandasabapathy, N., Aplin, A.E., Bertolotto, C., Bosenberg, M., Ceol, C.J., Chi, P., Herlyn, M., Holmen, S.L., Karreth, F.A., Kaufman, C.K., Khan, S., Kobold, S., Leucci, E., Levy, C., Lombard, D.B., Lund, A.W., Marie, K.L., Marine, J.C., Marais, R., McMahon, M., Robles-Espinoza, C.D., Ronai, Z.A., Samuels, Y., Soengas, M.S., Villanueva, J., Weeraratna, A.T., White, R.M., Yeh, I., Zhu, J., Zon, L.I., Hurlbert, M.S., Merlino, G. (2021) Melanoma models for the next generation of therapies. Cancer Cell. 39(5):610-631
Iwanaga, R., Truong, B.T., Hsu, J.Y., Lambert, K.A., Vyas, R., Orlicky, D., Shellman, Y.G., Tan, A.C., Ceol, C., Artinger, K.B. (2020) Loss of prdm1a accelerates melanoma onset and progression. Molecular Carcinogenesis. 59(9):1052-1063
Frantz, W.T., Ceol, C.J. (2020) From Tank to Treatment: Modeling Melanoma in Zebrafish. Cells. 9(5):
Gramann, A.K., Venkatesan, A.M., Guerin, M., Ceol, C.J. (2019) Regulation of zebrafish melanocyte development by ligand-dependent BMP signaling. eLIFE. 8:
Venkatesan, A.M., Vyas, R., Gramann, A.K., Dresser, K., Gujja, S., Bhatnagar, S., Chhangawala, S., Gomes, C.B.F., Xi, H.S., Lian, C.G., Houvras, Y., Edwards, Y.J.K., Deng, A., Green, M., Ceol, C.J. (2017) Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. The Journal of Clinical Investigation. 128(1):294-308
Neiswender, J.V., Kortum, R.L., Bourque, C., Kasheta, M., Zon, L., Morrison, D.K., Ceol, C.J. (2017) KIT Suppresses BRAFV600E-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.. Cancer research. 77(21):5820-5830
Kasheta, M., Painter, C.A., Moore, F.E., Lobbardi, R., Bryll, A., Freiman, E., Stachura, D., Rogers, A.B., Houvras, Y., Langenau, D.M., Ceol, C.J. (2017) Identification and characterization of T reg-like cells in zebrafish. The Journal of experimental medicine. 214(12):3519-3530
Tang, Q., Iyer, S., Lobbardi, R., Moore, J.C., Chen, H., Lareau, C., Hebert, C., Shaw, M.L., Neftel, C., Suva, M.L., Ceol, C.J., Bernards, A., Aryee, M., Pinello, L., Drummond, I.A., Langenau, D.M. (2017) Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing. The Journal of experimental medicine. 214(10):2875-2887
Neto, A., Ceol, C.J. (2017) Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling. Pigment cell & melanoma research. 31(1):115-119
Moore, F.E., Garcia, E.G., Lobbardi, R., Jain, E., Tang, Q., Moore, J.C., Cortes, M., Molodtsov, A., Kasheta, M., Luo, C.C., Garcia, A.J., Mylvaganam, R., Yoder, J.A., Blackburn, J.S., Sadreyev, R.I., Ceol, C.J., North, T.E., Langenau, D.M. (2016) Single-cell transcriptional analysis of normal, aberrant, and malignant hematopoiesis in zebrafish. The Journal of experimental medicine. 213(6):979-92
Wojciechowska, S., Zeng, Z., Lister, J.A., Ceol, C.J., Patton, E.E. (2016) Melanoma Regression and Recurrence in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:143-53
Ceol, C.J., Houvras, Y. (2016) Uncharted Waters: Zebrafish Cancer Models Navigate a Course for Oncogene Discovery. Advances in experimental medicine and biology. 916:3-19
Wojciechowska, S., van Rooijen, E., Ceol, C., Patton, E.E., White, R.M. (2016) Generation and analysis of zebrafish melanoma models. Methods in cell biology. 134:531-49
Iyengar, S., Kasheta, M., Ceol, C.J. (2015) Poised Regeneration of Zebrafish Melanocytes Involves Direct Differentiation and Concurrent Replenishment of Tissue-Resident Progenitor Cells. Developmental Cell. 33(6):631-43
Painter, C.A., Ceol, C.J. (2014) Zebrafish as a platform to study tumor progression. Methods in molecular biology (Clifton, N.J.). 1176:143-55
Iyengar, S., Houvras, Y., and Ceol, C.J. (2012) Screening for Melanoma Modifiers using a Zebrafish Autochthonous Tumor Model. Journal of visualized experiments : JoVE. (69):e50086
Richardson, J., Zeng, Z., Ceol, C., Mione, M., Jackson, I.J., and Patton, E.E. (2011) A zebrafish model for nevus regeneration. Pigment cell & melanoma research. 24(2):378-381
Ceol, C.J., Houvras, Y., Jane-Valbuena, J., Bilodeau, S., Orlando, D.A., Battisti, V., Fritsch, L., Lin, W.M., Hollmann, T.J., Ferré, F., Bourque, C., Burke, C.J., Turner, L., Uong, A., Johnson, L.A., Beroukhim, R., Mermel, C.H., Loda, M., Ait-Si-Ali, S., Garraway, L.A., Young, R.A., and Zon, L.I. (2011) The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset. Nature. 471(7339):513-517
North, T.E., Goessling, W., Peeters, M., Li, P., Ceol, C., Lord, A.M., Weber, G.J., Harris, J., Cutting, C.C., Huang, P., Dzierzak, E., and Zon, L.I. (2009) Hematopoietic stem cell development is dependent on blood flow. Cell. 137(4):736-748
Freeman, J.L., Ceol, C., Feng, H., Langenau, D.M., Belair, C., Stern, H.M., Song, A., Paw, B.H., Look, A.T., Zhou, Y., Zon, L.I., and Lee, C. (2009) Construction and application of a zebrafish array comparative genomic hybridization platform. Genes, chromosomes & cancer. 48(2):155-170
Ceol, C.J., Houvras, Y., White, R.M., and Zon, L.I. (2008) Melanoma biology and the promise of zebrafish. Zebrafish. 5(4):247-255
Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology. 320(1):161-174
Langenau, D.M., Keefe, M.D., Storer, N.Y., Jette, C.A., Smith, A.C., Ceol, C.J., Bourque, C., Look, A.T., and Zon, L.I. (2008) Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish. Oncogene. 27(30):4242-4248
White, R.M., Sessa, A., Burke, C., Bowman, T., LeBlanc, J., Ceol, C. Bourque, C., Dovey, M., Goessling, W., Burns, C.E., and Zon, L.I. (2008) Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis. Cell Stem Cell. 2(2):183-189

Ceol, C.J., Stegmeier, F., Harrison, M.M. and Horvitz, H.R. (2006). Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development. Genetics. 173, 709-26.

Ceol, C.J. and Horvitz, H.R. (2004). A new class of C. elegans synMuv genes implicates a Tip60/NuA4-like HAT complex as a negative regulator of Ras signaling. Dev. Cell. 6, 563-76.

Thomas, J.H.*, Ceol, C.J.*, Schwartz, H.T. and Horvitz, H.R. (2003). New genes that interact with lin-35 Rb to negatively regulate the let-60 ras pathway in Caenorhabditis elegans. Genetics. 164, 135-51.
* Equal contribution

Ceol, C.J. and Horvitz, H.R. (2001). dpl-1 DP and efl-1 E2F act with lin-35 Rb to antagonize Ras signaling in C. elegans vulval development. Mol. Cell. 7, 461-73.