PUBLICATION
BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development
- Authors
- Raldúa, D., and Babin, P.J.
- ID
- ZDB-PUB-071001-5
- Date
- 2007
- Source
- Toxicology letters 175(1-3): 1-7 (Journal)
- Registered Authors
- Babin, Patrick J., Raldúa, Demetrio
- Keywords
- BLT-1, Copper, High-density lipoproteins, SCARB1, Scavenger receptor class B type 1, Zebrafish
- MeSH Terms
-
- Animals
- Brain/abnormalities
- Brain/drug effects
- Chelating Agents/toxicity*
- Copper/metabolism*
- Copper/pharmacology
- Cyclopentanes/toxicity*
- Embryo, Nonmammalian/abnormalities
- Embryo, Nonmammalian/drug effects*
- Melanins/metabolism
- Notochord/abnormalities
- Notochord/drug effects
- Phenotype
- Protective Agents/pharmacology
- Scavenger Receptors, Class B/antagonists & inhibitors*
- Scavenger Receptors, Class B/metabolism
- Skin Pigmentation/drug effects
- Thiosemicarbazones/toxicity*
- Zebrafish/abnormalities*
- PubMed
- 17890024 Full text @ Toxicol. Lett.
- CTD
- 17890024
Citation
Raldúa, D., and Babin, P.J. (2007) BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicology letters. 175(1-3):1-7.
Abstract
Block lipid transport-1 (BLT-1) is a small chemical widely used to inhibit the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by scavenger receptor B, type 1 (SR-BI). This study demonstrated that BLT-1 induced in zebrafish (Danio rerio) embryos a copper-dependent phenotype with a twisted notochord, brain ventricle enlargement, and absence of melanisation, phenocopying neocuproine-treated, or calamity mutants. This finding supports an unexpected link between copper availability and SR-BI activity. The copper-chelating activity of BLT-1, revealed by its dramatic effect during embryo development, should be considered in any evaluation of the pharmacological effect of this thiosemicarbazone derivative on SR-BI activity and the potential therapeutic value of this molecule.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping