ZFIN Person: Babin, Patrick J.

ZFIN ID: ZDB-PERS-070326-1

ZFIN ID: ZDB-PERS-070326-1

Babin, Patrick J.

Email:	patrick.babin@u-bordeaux.fr
URL:	https://www.researchgate.net/profile/Patrick_Babin/
Affiliation:
Address:	Patrick J. Babin Professeur, Universités de Bordeaux et de Bordeaux Montaigne Laboratoire Maladies Rares: Génétique et Métabolisme (MRGM) (Rare Diseases: Genetic and Metabolism) Université de Bordeaux, INSERM U1211, Allée Geoffroy St-Hilaire, Bat. B2, 2ème étage, CS 50023 33615 Pessac cedex France Email: patrick.babin@u-bordeaux.fr Tel.: +33 (0)540008776
Country:	France
Phone:	+33 (0)540 008776
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Professor, University of Bordeaux, team leader

Keywords : lipid metabolism, lipoprotein, molecular evolution, zebrafish, trout, nutrigenomics, endogenous nutrition, comparative genomics, larval nutrition, intestine, adipose tissue, diet, developmental biology, apolipoproteins, nutrition, reproduction, lipid deposition, lipid mobilization, toxicology, obesogens and anti-obesogens, endocrine disruptors, thyroid gland.

PUBLICATIONS

Knoll-Gellida, A., Dubrana, L.E., Bourcier, L.M., Mercé, T., Gruel, G., Soares, M., Babin, P.J. (2021) Hyperactivity and Seizure Induced by Tricresyl Phosphate Are Isomer-Specific and Not Linked to Phenyl Valerate-Neuropathy Target Esterase Activity Inhibition in Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 180(1):160-174

Audouze, K., Sarigiannis, D., Alonso-Magdalena, P., Brochot, C., Casas, M., Vrijheid, M., Babin, P.J., Karakitsios, S., Coumoul, X., Barouki, R. (2020) Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project. International Journal of Molecular Sciences. 21(8)

Lutfi, E., Babin, P.J., Gutiérrez, J., Capilla, E., Navarro, I. (2017) Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models. PLoS One. 12:e0178833

Tingaud-Sequeira, A., Raldúa, D., Lavie, J., Mathieu, G., Bordier, M., Knoll-Gellida, A., Rambeau, P., Coupry, I., André, M., Malm, E., Möller, C., Andreasson, S., Rendtorff, N.D., Tranebjærg, L., Koenig, M., Lacombe, D., Goizet, C., Babin, P.J. (2017) Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiology of disease. 98:36-51

Lopez, E., Berenguer, M., Tingaud-Sequeira, A., Marlin, S., Toutain, A., Denoyelle, F., Picard, A., Charron, S., Mathieu, G., de Belvalet, H., Arveiler, B., Babin, P.J., Lacombe, D., Rooryck, C. (2016) Mutations in MYT1, encoding the myelin transcription factor 1, are a rare cause of OAVS.. Journal of Medical Genetics. 53(11):752-760

Ouadah-Boussouf, N., Babin, P.J. (2016) Pharmacological evaluation of the mechanisms involved in increased adiposity in zebrafish triggered by the environmental contaminant tributyltin. Toxicology and applied pharmacology. 294:32-42

Esteves, A., Knoll-Gellida, A., Canclini, L., Silvarrey, M.C., André, M., Babin, P.J. (2016) Fatty acid-binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei. Journal of Lipid Research. 57(2):219-32

Faria, M., Garcia-Reyero, N., Padrós, F., Babin, P.J., Sebastián, D., Cachot, J., Prats, E., Arick, M., Rial, E., Knoll-Gellida, A., Mathieu, G., Le Bihanic, F., Lynn Escalon, B., Zorzano, A., Soares, A.M., Raldúa, D. (2016) Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning. Scientific Reports. 6:17244

Faria, M., Garcia-Reyero, N., Padrós, F., Babin, P.J., Sebastián, D., Cachot, J., Prats, E., Arick Ii, M., Rial, E., Knoll-Gellida, A., Mathieu, G., Le Bihanic, F., Escalon, B.L., Zorzano, A., Soares, A.M., Raldúa, D. (2015) Zebrafish Models for Human Acute Organophosphorus Poisoning. Scientific Reports. 5:15591

Babin, P.J., Goizet, C., Raldúa, D. (2014) Zebrafish models of human motor neuron diseases: Advantages and limitations. Prog. Neurobiol.. 118C:36-58

Garcia-Reyero, N., Escalon, B.L., Prats, E., Stanley, J.K., Thienpont, B., Melby, N.L., Barón, E., Eljarrat, E., Barceló, D., Mestres, J., Babin, P.J., Perkins, E.J., and Raldúa, D. (2014) Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health. Environment International. 63:216-223

Pelayo, S., Oliveira, E., Thienpont, B., Babin, P.J., Raldúa, D., André, M., and Piña, B. (2012) Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: Implications for bisphenol A developmental toxicity. Aquatic toxicology (Amsterdam, Netherlands). 110-111C:114-122

Raldúa, D., Thienpont, B., and Babin, P.J. (2012) Zebrafish eleutheroembryos as an alternative system for screening chemicals disrupting the mammalian thyroid gland morphogenesis and function. Reproductive toxicology (Elmsford, N.Y.). 33(2):188-197

Tingaud-Sequeira, A., Knoll-Gellida, A., André, M., and Babin, P.J. (2012) Vitellogenin Expression in White Adipose Tissue in Female Teleost Fish. Biology of reproduction. 86(2):38

Tingaud-Sequeira, A., Ouadah, N., and Babin, P.J. (2011) Zebrafish obesogenic test: a tool for screening molecules that target adiposity. Journal of Lipid Research. 52(9):1765-1772

Thienpont, B., Tingaud-Sequeira, A., Prats, E., Barata, C., Babin, P.J., and Raldúa, D. (2011) Zebrafish Eleutheroembryos Provide a Suitable Vertebrate Model for Screening Chemicals that Impair Thyroid Hormone Synthesis. Environmental science & technology. 45(7):7525-7532

Raldúa, D., and Babin, P.J. (2009) Simple, rapid zebrafish larva bioassay for assessing the potential of chemical pollutants and drugs to disrupt thyroid gland function. Environmental science & technology. 43(17):6844-6850

Raldúa, D., André, M., and Babin, P.J. (2008) Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. Toxicology and applied pharmacology. 228(3):301-314

Babin, P.J. (2008) Conservation of a vitellogenin gene cluster in oviparous vertebrates and identification of its traces in the platypus genome. Gene. 413(1-2):76-82

Raldúa, D., and Babin, P.J. (2007) BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicology letters. 175(1-3):1-7

Agulleiro, M.J., Andre, M., Morais, S., Cerda, J., and Babin, P.J. (2007) High Transcript Level of Fatty Acid-Binding Protein 11 But Not of Very Low-Density Lipoprotein Receptor Is Correlated to Ovarian Follicle Atresia in a Teleost Fish (Solea senegalensis). Biology of reproduction. 77(3):504-516

Morais, S., Knoll-Gellida, A., Andre, M., Barthe, C., and Babin, P.J. (2007) Conserved expression of alternative splicing variants of peroxisomal acyl-CoA oxidase 1 in vertebrates and developmental and nutritional regulation in fish. Physiological Genomics. 28(3):239-252

Tingaud-Sequeira, A., Forgue, J., Andre, M., and Babin, P.J. (2006) Epidermal transient down-regulation of retinol-binding protein 4 and mirror expression of apolipoprotein Eb and estrogen receptor 2a during zebrafish fin and scale development. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(11):3071-3079

Knoll-Gellida, A., Andre, M., Gattegno, T., Forgue, J., Admon, A., and Babin, P.J. (2006) Molecular phenotype of zebrafish ovarian follicle by serial analysis of gene expression and proteomic profiling, and comparison with the transcriptomes of other animals. BMC Genomics. 7(1):46

Marza, E., Barthe, C., André, M., Villeneuve, L., Hélou, C., and Babin, P.J. (2005) Developmental expression and nutritional regulation of a zebrafish gene homologous to mammalian microsomal triglyceride transfer protein large subunit. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(2):506-518

Cotto, E., Andre, M., Forgue, J., Fleury, H.J., and Babin, P.J. (2005) Molecular characterization, phylogenetic relationships, and developmental expression patterns of prion genes in zebrafish (Danio rerio). The FEBS journal. 272(2):500-513

Tingaud-Sequeira, A., André, M., Forgue, J., Barthe, C., and Babin, P.J. (2004) Expression patterns of three estrogen receptor genes during zebrafish (Danio rerio) development: evidence for high expression in neuromasts. Gene expression patterns : GEP. 4(5):561-568

Poupard, G., Andre, M., Durliat, M., Ballagny, C., Boeuf, G., and Babin, P.J. (2000) Apolipoprotein E gene expression correlates with endogenous lipid nutrition and yolk syncytial layer lipoprotein synthesis during fish development. Cell and tissue research. 300(2):251-261

Andre, M., Ando, S., Ballagny, C., Durliat, M., Poupard, G., Briancon, C., and Babin, P.J. (2000) Intestinal fatty acid binding protein gene expression reveals the cephalocaudal patterning during zebrafish gut morphogenesis. The International journal of developmental biology. 44(2):249-252

Durliat, M., Andre, M., and Babin, P.J. (2000) Conserved protein motifs and structural organization of a fish gene homologous to mammalian apolipoprotein E. European journal of biochemistry. 267(2):549-559

Monnot, M.J., Babin, P.J., Poleo, G., Andre, M., Laforest, L., Ballagny, C., and Akimenko, M.A. (1999) Epidermal expression of apolipoprotein E gene during fin and scale development and fin regeneration in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 214(3):207-215

Babin, P.J., Thisse, C., Durliat, M., Andre, M., Akimenko, M.-A., and Thisse, B. (1997) Both apolipoprotein E and A-I genes are present in a nonmammalian vertebrate and are highly expressed during embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 94(16):8622-8627

NON-ZEBRAFISH PUBLICATIONS
Marelli C, Lamari F, Rainteau D, Lafourcade A, Banneau G, Humbert L, Monin ML, Petit E, Debs R, Castelnovo G, Ollagnon E, Lavie J, Pilliod J, Coupry I, Babin PJ, Guissart C, Benyounes I, Ullmann U, Lesca G, Thauvin-Robinet C, Labauge P, Odent S, Ewenczyk C, Wolf C, Stevanin G, Hajage D, Durr A, Goizet C, Mochel F. (2018). Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5. Brain 141, 72-84.

Durand CM, Dhers L, Tesson C, Tessa A, Fouillen L, Jacqueré S, Raymond L, Coupry I, Benard G, Darios F, El-Hachimi KH, Astrea G, Rivier F, Banneau G, Pujol C, Lacombe D, Durr A, Babin PJ, Santorelli FM, Pietrancosta N, Boucher JL, Mansuy D, Stevanin G, Goizet C. (2018). CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56. Hum Mut 39, 140-151.

Babin PJ, Gibbons GF. (2009). The evolution of plasma cholesterol: Direct utility or a spandrel of hepatic lipid metabolism? Prog. Lipid Res. 48: 73-91.

Cerda J; J, Bobe J, Babin PJ, Admon A, Lubzens E (2008). Functional genomics and proteomic approaches for the study of gamete quality in finfish aquaculture. Reviews in Fisheries Science, 16(S1) : 54-70.

Avarre, J.C., Lubzens, E., and Babin, P.J. (2007). Apolipocrustacein, formerly vitellogenin, is the major egg yolk precursor protein in decapod crustaceans and is homologous to insect apolipophorin II/I and vertebrate apolipoprotein B. BMC Evol. Biol. 7:3.

Babin, P.J. (2002). New insights from genomics on the molecular basis of lipoprotein metabolism in fish. Fisheries Sciences 68 (supp): 1185-1189.

Sammar, M., Babin, P.J., Durliat, M., Zmeiri, I., Zchori, I., Elizur, A., and Lubzens, E. (2001) Retinol binding protein in rainbow trout: molecular characterization, expression and regulation by 17�-estradiol. Gen. Comp. Endocrinol. 123:51-61.

Khayat, M, Babin, PJ, Funkenstein, B, Sammar, M, Nagasawa, H, Tietz, A, and Lubzens, E (2001). Molecular characterization and high expression during oocyte development of a shrimp ovarian cortical rod protein homologous to insect intestinal peritrophins. Biol. Reprod. 64:1090-1099.

Poupard, G., Andre;, M., Durliat, M., Ballagny, C., Boeuf, G., and Babin, P.J. (2000). Apolipoprotein E gene expression correlates with endogenous lipid nutrition and yolk syncytial layer lipoprotein synthesis during fish development. Cell Tissue Res. 300:251-261.

Bogerd, J., Babin, P.J., Kooiman, F.P., Andre;, M., Ballagny, C., Van Marrewijk, W.J.A., and Van der Horst, D. (2000). Molecular characterization and gene expression in the eye of the apolipophorin II/I precursor from Locusta migratoria. J. Comp. Neurol. 427:546-558.

Babin P.J., Bogerd J., Kooiman F.P., Van Marrewijk W., and Van der Horst D. (1999). Apolipophorin II/I, apolipoprotein B, vitellogenin, and microsomal triglyceride transfer protein genes are derived from a common ancestor. J. Mol. Evol. 49:150-160.

Babin P.J., Deryckere F., and Gannon F. (1995). Presence of an extended duplication in the low density lipoprotein receptor-binding domain of apolipoprotein B. Cloning and characterization of the domain in salmon. Eur. J. Biochem. 230:45-51.

Wallaert, C., and Babin, P.J. (1995). Frozen storage affects high density lipoproteins and the quantitation of trout (Oncorhynchus mykiss) lipoprotein classes as separated by ultracentrifugation. Comp. Biochem. Physiol. 110B:439-444.

Wallaert, C., and Babin, P.J. (1994). Age-related, sex-related and seasonal changes of plasma lipoprotein concentrations in trout. J. Lipid Res. 35:1619-1633.

Wallaert, C., and Babin, P.J. (1994). Effects of temperature variations on dietary lipid absorption and plasma lipoprotein concentrations in trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. 109B:473-487.

Wallaert, C., and Babin, P.J. (1994). Thermal adaptation affects the fatty acid composition of plasma phospholipids in trout. Lipids 29:373-376.

Sire, M.F., Babin, P.J., and Vernier, J.M. (1994). Involvement of the lysosomal system in yolk protein deposit and degradation during vitellogenesis and embryonic development in trout. J. Exp. Zool. 269:69-83.

Babin, PJ (1993). Binding of thyroxine and 3,5,3'-triiodothyronine to trout plasma lipoproteins. The Year Book of Endocrinology 97-100.

Wallaert, C, and Babin, PJ (1993). Circannual variation in the fatty acid composition of high-density lipoprotein phospholipids during acclimatization in trout. Biochim. Biophys. Acta 1210:23-26.

Babin, P.J. (1992). Binding of thyroxine and 3,5,3'-triiodothyronine to trout plasma lipoproteins. Am. J. Physiol. 262:E712-E720.

Wallaert, C., and Babin, P.J. (1992). Effects of 17beta-estradiol and starvation on trout plasma lipoproteins. Lipids 27:1032-1041.

Babin, P.J., and Vernier, J.M. (1989). Plasma lipoproteins in fish: a review. J. Lipid Res. 30:467-489.

Babin, P.J. (1987). Apolipoproteins and the association of egg yolk proteins with plasma high density lipoproteins after ovulation and follicular atresia in the rainbow trout (Salmo gairdneri). J. Biol. Chem. 262:4290-4296.

Babin, P.J. (1987). Plasma lipoproteins and apolipoproteins distribution as a function of density in the rainbow trout (Salmo gairdneri). Biochem. J. 246:425-429.

Babin, P.J. (1986). Effects of plasma lipoproteins in gonadotropin stimulation of 17b-estradiol production in the ovarian follicle of rainbow trout (Salmo gairdneri). Gen. Comp. Endocrinol. 64:456-467.