ZFIN ID: ZDB-PERS-111018-1
Raldúa, Demetrio
Email: drpqam@cid.csic.es
URL:
Affiliation:
Address: Department Environmental Chemistry IDAEA-CSIC Jordi Girona 18 08034 Barcelona Spain
Country:
Phone: +34934006100
Fax: +34932045904
ORCID ID: 0000-0001-5256-1641


BIOGRAPHY AND RESEARCH INTERESTS
Biography and Research Interests:
Scientist at Spanish Research Council (Group Leader)

Research of interest : My current research interest is the understanding of the molecular bases of the neurotoxic effects of some environmental pollutants and drugs. By using zebrafish as vertebrate model, we try to identify the AOPs of neurotoxicants, by linking adverse effects from the molecular-initiating events to behavioural effects.


PUBLICATIONS
Bellot, M., Carrillo, M.P., Bedrossiantz, J., Zheng, J., Mandal, R., Wishart, D.S., Gómez-Canela, C., Vila-Costa, M., Prats, E., Piña, B., Raldúa, D. (2023) From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish. Ecotoxicology and environmental safety. 270:115888115888
Bellot, M., Manen, L., Prats, E., Bedrossiantz, J., Barata, C., Gómez-Canela, C., Antolin, A.A., Raldúa, D. (2023) Short-term exposure to environmental levels of nicotine and cotinine impairs visual motor response in zebrafish larvae through a similar mode of action: Exploring the potential role of zebrafish α7 nAChR. The Science of the total environment. 912:169301
Ricarte, M., Prats, E., Bedrossiantz, J., Raldúa, D. (2023) Analysis of sleep/wake cycles in zebrafish larvae. MethodsX. 12:102492102492
Correia, D., Bellot, M., Prats, E., Gómez-Canela, C., Moro, H., Raldúa, D., Domingues, I., Oliveira, M., Faria, M. (2023) Impact of environmentally relevant concentrations of fluoxetine on zebrafish larvae: From gene to behavior. Chemosphere. 345:140468
Teixidó, E., Riera-Colomer, C., Raldúa, D., Pubill, D., Escubedo, E., Barenys, M., López-Arnau, R. (2023) First-Generation Synthetic Cathinones Produce Arrhythmia in Zebrafish Eleutheroembryos: A New Approach Methodology for New Psychoactive Substances Cardiotoxicity Evaluation. International Journal of Molecular Sciences. 24(18):
Ricarte, M., Prats, E., Montemurro, N., Bedrossiantz, J., Bellot, M., Gómez-Canela, C., Raldúa, D. (2023) Environmental concentrations of tire rubber-derived 6PPD-quinone alter CNS function in zebrafish larvae. The Science of the total environment. 896:165240
Bedrossiantz, J., Faria, M., Prats, E., Barata, C., Cachot, J., Raldúa, D. (2022) Heart rate and behavioral responses in three phylogenetically distant aquatic model organisms exposed to environmental concentrations of carbaryl and fenitrothion. The Science of the total environment. 865:161268
Faria, M., Bellot, M., Soto, O., Prats, E., Montemurro, N., Manjarrés, D., Gómez-Canela, C., Raldúa, D. (2022) Developmental exposure to sertraline impaired zebrafish behavioral and neurochemical profiles. Frontiers in Physiology. 13:10405981040598
Bedrossiantz, J., Bellot, M., Dominguez-García, P., Faria, M., Prats, E., Gómez-Canela, C., López-Arnau, R., Escubedo, E., Raldúa, D. (2021) A Zebrafish Model of Neurotoxicity by Binge-Like Methamphetamine Exposure. Frontiers in pharmacology. 12:770319
Rosas-Ramírez, J.R., Orozco-Hernández, J.M., Elizalde-Velázquez, G.A., Raldúa, D., Islas-Flores, H., Gómez-Oliván, L.M. (2021) Teratogenic effects induced by paracetamol, ciprofloxacin, and their mixture on Danio rerio embryos: Oxidative stress implications. The Science of the total environment. 806:150541
Faria, M., Prats, E., Bellot, M., Gomez-Canela, C., Raldúa, D. (2021) Pharmacological Modulation of Serotonin Levels in Zebrafish Larvae: Lessons for Identifying Environmental Neurotoxicants Targeting the Serotonergic System. Toxics. 9(6):
Bellot, M., Bartolomé, H., Faria, M., Gómez-Canela, C., Raldúa, D. (2021) Differential Modulation of the Central and Peripheral Monoaminergic Neurochemicals by Deprenyl in Zebrafish Larvae. Toxics. 9(6):
Faria, M., Bedrossiantz, J., Ramírez, J.R.R., Mayol, M., García, G.H., Bellot, M., Prats, E., Garcia-Reyero, N., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2020) Glyphosate targets fish monoaminergic systems leading to oxidative stress and anxiety. Environment International. 146:106253
Mayol-Cabré, M., Prats, E., Raldúa, D., Gómez-Canela, C. (2020) Characterization of monoaminergic neurochemicals in the different brain regions of adult zebrafish. The Science of the total environment. 745:141205
Pérez, Y., Casado, M., Raldúa, D., Prats, E., Piña, B., Tauler, R., Alfonso, I., Puig-Castellví, F. (2020) MCR-ALS analysis of 1H NMR spectra by segments to study the zebrafish exposure to acrylamide. Analytical and bioanalytical chemistry. 412(23):5695-5706
Faria, M., Prats, E., Gómez-Canela, C., Hsu, C.Y., Arick, M.A., Bedrossiantz, J., Orozco, M., Garcia-Reyero, N., Ziv, T., Ben-Lulu, S., Admon, A., Gómez-Oliván, L.M., Raldúa, D. (2020) Publisher Correction: Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Scientific Reports. 10:2247
Faria, M., Wu, X., Luja-Mondragón, M., Prats, E., Gómez-Oliván, L.M., Piña, B., Raldúa, D. (2020) Screening anti-predator behaviour in fish larvae exposed to environmental pollutants. The Science of the total environment. 714:136759
Raldúa, D., Casado, M., Prats, E., Faria, M., Puig-Castellví, F., Pérez, Y., Alfonso, I., Hsu, C.Y., Arick Ii, M.A., Garcia-Reyero, N., Ziv, T., Ben-Lulu, S., Admon, A., Piña, B. (2020) Targeting redox metabolism: the perfect storm induced by acrylamide poisoning in the brain. Scientific Reports. 10:312
Faria, M., Prats, E., Gómez-Canela, C., Hsu, C.Y., Arick, M.A., Bedrossiantz, J., Orozco, M., Garcia-Reyero, N., Ziv, T., Ben-Lulu, S., Admon, A., Gómez-Oliván, L.M., Raldúa, D. (2019) Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Scientific Reports. 9:16467
Faria, M., Valls, A., Prats, E., Bedrossiantz, J., Orozco, M., Porta, J.M., Gómez-Oliván, L.M., Raldúa, D. (2019) Further characterization of the zebrafish model of acrylamide acute neurotoxicity: gait abnormalities and oxidative stress. Scientific Reports. 9:7075
Martínez, R., Navarro-Martín, L., Luccarelli, C., Codina, A.E., Raldúa, D., Barata, C., Tauler, R., Piña, B. (2019) Unravelling the mechanisms of PFOS toxicity by combining morphological and transcriptomic analyses in zebrafish embryos. The Science of the total environment. 674:462-471
Faria, M., Bedrossiantz, J., Prats, E., Rovira Garcia, X., Gómez-Canela, C., Piña, B., Raldúa, D. (2019) Deciphering the mode of action of pollutants impairing the fish larvae escape response with the vibrational startle response assay. The Science of the total environment. 672:121-128
Olmos, V., Marro, M., Loza-Alvarez, P., Raldúa, D., Prats, E., Piña, B., Tauler, R., de Juan, A. (2019) Assessment of tissue-specific multifactor effects in environmental -omics studies of heterogeneous biological samples: Combining hyperspectral image information and chemometrics. Talanta. 194:390-398
Martínez, R., Esteve-Codina, A., Herrero-Nogareda, L., Ortiz-Villanueva, E., Barata, C., Tauler, R., Raldúa, D., Piña, B., Navarro-Martín, L. (2018) Dose-dependent transcriptomic responses of zebrafish eleutheroembryos to Bisphenol A. Environmental pollution (Barking, Essex : 1987). 243:988-997
Faria, M., Prats, E., Novoa-Luna, K.A., Bedrossiantz, J., Gómez-Canela, C., Gómez-Oliván, L.M., Raldúa, D. (2018) Development of a vibrational startle response assay for screening environmental pollutants and drugs impairing predator avoidance. The Science of the total environment. 650:87-96
Gómez-Canela, C., Prats, E., Lacorte, S., Raldúa, D., Piña, B., Tauler, R. (2018) Metabolomic changes induced by nicotine in adult zebrafish skeletal muscle. Ecotoxicology and environmental safety. 164:388-397
Faria, M., Ziv, T., Gómez-Canela, C., Ben-Lulu, S., Prats, E., Novoa-Luna, K.A., Admon, A., Piña, B., Tauler, R., Gómez-Oliván, L.M., Raldúa, D. (2018) Acrylamide acute neurotoxicity in adult zebrafish. Scientific Reports. 8:7918
Faria, M., Fuertes, I., Prats, E., Abad, J.L., Padrós, F., Gomez-Canela, C., Casas, J., Estevez, J., Vilanova, E., Piña, B., Raldúa, D. (2018) Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish. Scientific Reports. 8:4844
Gómez-Canela, C., Tornero-Cañadas, D., Prats, E., Piña, B., Tauler, R., Raldúa, D. (2018) Comprehensive characterization of neurochemicals in three zebrafish chemical models of human acute organophosphorus poisoning using liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry. 410(6):1735-1748
Piña, B., Navarro, L., Barata, C., Raldúa, D., Martínez, R., Casado, M. (2018) Omics in Zebrafish Teratogenesis. Methods in molecular biology (Clifton, N.J.). 1797:421-441
Gómez-Canela, C., Prats, E., Tauler, R., Raldúa, D. (2017) Analysis of neurobehavioural data by chemometric methods in ecotoxicological studies. Ecotoxicology and environmental safety. 145:583-590
Prats, E., Gómez-Canela, C., Ben-Lulu, S., Ziv, T., Padrós, F., Tornero, D., Garcia-Reyero, N., Tauler, R., Admon, A., Raldúa, D. (2017) Modelling acrylamide acute neurotoxicity in zebrafish larvae. Scientific Reports. 7:13952
Faria, M., Prats, E., Padrós, F., Soares, A.M., Raldúa, D. (2017) Zebrafish is a predictive model for identifying compounds that protect against brain toxicity in severe acute organophosphorus intoxication. Archives of toxicology. 91(4):1891-1901
Tingaud-Sequeira, A., Raldúa, D., Lavie, J., Mathieu, G., Bordier, M., Knoll-Gellida, A., Rambeau, P., Coupry, I., André, M., Malm, E., Möller, C., Andreasson, S., Rendtorff, N.D., Tranebjærg, L., Koenig, M., Lacombe, D., Goizet, C., Babin, P.J. (2017) Functional validation of ABHD12 mutations in the neurodegenerative disease PHARC. Neurobiology of disease. 98:36-51
Garcia-Reyero, N., Escalon, L., Prats, E., Faria, M., Soares, A.M., Raldúa, D. (2016) Targeted Gene Expression in Zebrafish Exposed to Chlorpyrifos-Oxon Confirms Phenotype-Specific Mechanisms Leading to Adverse Outcomes. Bulletin of environmental contamination and toxicology. 96(6):707-713
Faria, M., Garcia-Reyero, N., Padrós, F., Babin, P.J., Sebastián, D., Cachot, J., Prats, E., Arick, M., Rial, E., Knoll-Gellida, A., Mathieu, G., Le Bihanic, F., Lynn Escalon, B., Zorzano, A., Soares, A.M., Raldúa, D. (2016) Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning. Scientific Reports. 6:17244
Faria, M., Garcia-Reyero, N., Padrós, F., Babin, P.J., Sebastián, D., Cachot, J., Prats, E., Arick Ii, M., Rial, E., Knoll-Gellida, A., Mathieu, G., Le Bihanic, F., Escalon, B.L., Zorzano, A., Soares, A.M., Raldúa, D. (2015) Zebrafish Models for Human Acute Organophosphorus Poisoning. Scientific Reports. 5:15591
Babin, P.J., Goizet, C., Raldúa, D. (2014) Zebrafish models of human motor neuron diseases: Advantages and limitations. Prog. Neurobiol.. 118C:36-58
Raldúa, D., Piña, B. (2014) In vivo zebrafish assays for analyzing drug toxicity. Expert opinion on drug metabolism & toxicology. 10:685-97
Garcia-Reyero, N., Escalon, B.L., Prats, E., Stanley, J.K., Thienpont, B., Melby, N.L., Barón, E., Eljarrat, E., Barceló, D., Mestres, J., Babin, P.J., Perkins, E.J., and Raldúa, D. (2014) Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health. Environment International. 63:216-223
Oliveira, E., Casado, M., Raldúa, D., Soares, A., Barata, C., and Piña, B. (2013) Retinoic acid receptors' expression and function during zebrafish early development. The Journal of steroid biochemistry and molecular biology. 138:143-51
Thienpont, B., Barata, C., and Raldúa, D. (2013) Modeling mixtures of thyroid gland function disruptors in a vertebrate alternative model, the zebrafish eleutheroembryo. Toxicology and applied pharmacology. 269(2):169-75
Pelayo, S., Oliveira, E., Thienpont, B., Babin, P.J., Raldúa, D., André, M., and Piña, B. (2012) Triiodothyronine-induced changes in the zebrafish transcriptome during the eleutheroembryonic stage: Implications for bisphenol A developmental toxicity. Aquatic toxicology (Amsterdam, Netherlands). 110-111C:114-122
Raldúa, D., Thienpont, B., and Babin, P.J. (2012) Zebrafish eleutheroembryos as an alternative system for screening chemicals disrupting the mammalian thyroid gland morphogenesis and function. Reproductive toxicology (Elmsford, N.Y.). 33(2):188-197
Thienpont, B., Tingaud-Sequeira, A., Prats, E., Barata, C., Babin, P.J., and Raldúa, D. (2011) Zebrafish Eleutheroembryos Provide a Suitable Vertebrate Model for Screening Chemicals that Impair Thyroid Hormone Synthesis. Environmental science & technology. 45(7):7525-7532
Raldúa, D., and Babin, P.J. (2009) Simple, rapid zebrafish larva bioassay for assessing the potential of chemical pollutants and drugs to disrupt thyroid gland function. Environmental science & technology. 43(17):6844-6850
Raldúa, D., André, M., and Babin, P.J. (2008) Clofibrate and gemfibrozil induce an embryonic malabsorption syndrome in zebrafish. Toxicology and applied pharmacology. 228(3):301-314
Raldúa, D., and Babin, P.J. (2007) BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicology letters. 175(1-3):1-7

NON-ZEBRAFISH PUBLICATIONS
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