ZFIN Morpholino: MO1-esr2a

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-esr2a

No data available

Phenotype

Phenotype resulting from MO1-esr2a

Phenotype	Fish	Figures
hatching disrupted, abnormal	WT + MO1-esr2a	Fig. 2 from Froehlicher et al., 2009
neuromast absent, abnormal	WT + MO1-esr2a	Fig. 2 from Froehlicher et al., 2009
neuromast decreased amount, abnormal	WT + MO1-esr2a	Fig. 2 , Fig. 3 , Fig. 4 from Froehlicher et al., 2009
post-vent region increased curvature, abnormal	WT + MO1-esr2a	Fig. 2 from Froehlicher et al., 2009
ventral wall of dorsal aorta runx1 expression increased amount, abnormal	WT + MO1-esr2a	Fig. 2 from Carroll et al., 2014

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Phenotype of all Fish created by or utilizing MO1-esr2a

Phenotype	Fish	Conditions	Figures
ventral wall of dorsal aorta runx1 expression decreased amount, abnormal	WT + MO1-esr2a	chemical treatment by environment: 17beta-estradiol	Fig. 2 from Carroll et al., 2014
whole organism dead, abnormal	WT + MO1-esr2a	standard conditions	Fig. 2 from Froehlicher et al., 2009
neuromast absent, abnormal	WT + MO1-esr2a	standard conditions	Fig. 2 from Froehlicher et al., 2009
neuromast decreased amount, abnormal	WT + MO1-esr2a	standard conditions	Fig. 2 , Fig. 3 , Fig. 4 from Froehlicher et al., 2009
post-vent region increased curvature, abnormal	WT + MO1-esr2a	standard conditions	Fig. 2 from Froehlicher et al., 2009

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Citations

Include unpublished citations

Chaturantabut, S., Shwartz, A., Garnaas, M.K., LaBella, K., Li, C.C., Carroll, K.J., Cutting, C.C., Budrow, N., Palaria, A., Gorelick, D.A., Tremblay, K.D., North, T.E., Goessling, W. (2020) Estrogen acts via estrogen receptor 2b to regulate hepatobiliary fate during vertebrate development. Hepatology (Baltimore, Md.). 72(5):1786-1799
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53
Gorelick, D.A., Iwanowicz, L.R., Hung, A.L., Blazer, V.S., and Halpern, M.E. (2014) Transgenic Zebrafish Reveal Tissue-Specific Differences in Estrogen Signaling in Response to Environmental Water Samples. Environmental health perspectives. 122(4):356-62
Froehlicher, M., Liedtke, A., Groh, K., Lopez-Schier, H., Neuhauss, S.C., Segner, H., and Eggen, R.I. (2009) Estrogen receptor subtype beta2 is involved in neuromast development in zebrafish (Danio rerio) larvae. Developmental Biology. 330(1):32-43

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