Gene

esr2a

ID
ZDB-GENE-030116-2
Name
estrogen receptor 2a
Symbol
esr2a Nomenclature History
Previous Names
  • ER[b]2 (1)
  • ER[b]a (1)
  • ERbeta-B (1)
  • NR3A2-B (1)
  • zfER[b]2 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Exhibits estrogen receptor activity; nuclear receptor activity; and steroid hormone binding activity. Involved in response to estrogen. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); arthritis (multiple); autoimmune hypersensitivity disease (multiple); hypospadias; and neurodegenerative disease (multiple). Is expressed in several structures, including blastodisc; brain; pelvic fin bud; pleuroperitoneal region; and sensory system. Orthologous to human ESR2 (estrogen receptor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
34 figures from 23 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
11 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With esr2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ovarian dysgenesis 8 Alliance ?Ovarian dysgenesis 8 618187
Associated With esr2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Domain IPR021064 Estrogen receptor beta, N-terminal
Family IPR001723 Nuclear hormone receptor
Family IPR024178 Oestrogen receptor/oestrogen-related receptor
Family IPR028355 Estrogen receptor beta/gamma
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Estrogen receptor beta/gamma Estrogen receptor beta, N-terminal Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Oestrogen receptor/oestrogen-related receptor Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:U3PXZ5 143
UniProtKB:Q98SM7 553
UniProtKB:Q7ZU32 553
UniProtKB:U3Q062 81
UniProtKB:Q8AV62 553
UniProtKB:Q90WS8 553
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations