ZFIN Morpholino: MO4-sox2

Target Location

Genome Build: GRCz11Chromosome: 22

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO4-sox2

No data available

Phenotype

Phenotype resulting from MO4-sox2

Phenotype	Fish	Figures
eye decreased size, abnormal	WT + MO4-sox2	Fig. 3 from Chassaing et al., 2016
somite shape, abnormal	WT + MO4-sox2	Fig. S3 from Chassaing et al., 2016
whole organism gli1 expression increased amount, abnormal	WT + MO4-sox2	Fig. 5 from Chassaing et al., 2016
whole organism ptch1 expression increased amount, abnormal	WT + MO4-sox2	Fig. 5 from Chassaing et al., 2016

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Phenotype of all Fish created by or utilizing MO4-sox2

Phenotype	Fish	Conditions	Figures
caudal fin upturned, abnormal	WT + MO3-sox2 + MO4-sox2	standard conditions	Fig. 1 from Okuda et al., 2010
somite shape, abnormal	WT + MO4-sox2	standard conditions	Fig. S3 from Chassaing et al., 2016
whole organism ptch1 expression increased amount, abnormal	WT + MO4-sox2	standard conditions	Fig. 5 from Chassaing et al., 2016
whole organism gli1 expression increased amount, abnormal	WT + MO4-sox2	standard conditions	Fig. 5 from Chassaing et al., 2016
eye decreased size, abnormal	WT + MO4-sox2	standard conditions	Fig. 3 from Chassaing et al., 2016

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Citations

Include unpublished citations

Gao, M., Veil, M., Rosenblatt, M., Riesle, A.J., Gebhard, A., Hass, H., Buryanova, L., Yampolsky, L.Y., Grüning, B., Ulianov, S.V., Timmer, J., Onichtchouk, D. (2022) Pluripotency factors determine gene expression repertoire at zygotic genome activation. Nature communications. 13:788
Chassaing, N., Davis, E.E., McKnight, K.L., Niederriter, A.R., Causse, A., David, V., Desmaison, A., Lamarre, S., Vincent-Delorme, C., Pasquier, L., Coubes, C., Lacombe, D., Rossi, M., Dufier, J.L., Dollfus, H., Kaplan, J., Katsanis, N., Etchevers, H.C., Faguer, S., Calvas, P. (2016) Targeted resequencing identifies PTCH1 as a major contributor to ocular developmental anomalies and extends the SOX2 regulatory network. Genome research. 26(4):474-85
Hagey, D.W., Zaouter, C., Combeau, G., Andersson Lendahl, M., Andersson, O., Huss, M., Muhr, J. (2016) Distinct transcription factor complexes act on a permissive chromatin landscape to establish regionalized gene expression in CNS stem cells. Genome research. 26(7):908-17
Lee, M.T., Bonneau, A.R., Takacs, C.M., Bazzini, A.A., Divito, K.R., Fleming, E.S., and Giraldez, A.J. (2013) Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition. Nature. 503(7476):360-4
Leichsenring, M., Maes, J., Mössner, R., Driever, W., and Onichtchouk, D. (2013) Pou5f1 transcription factor controls zygotic gene activation in vertebrates. Science (New York, N.Y.). 341(6149):1005-1009
Okuda, Y., Ogura, E., Kondoh, H., and Kamachi, Y. (2010) B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo. PLoS Genetics. 6:e1000936
Kamachi, Y., Okuda, Y., and Kondoh, H. (2008) Quantitative assessment of the knockdown efficiency of morpholino antisense oligonucleotides in zebrafish embryos using a luciferase assay. Genesis (New York, N.Y. : 2000). 46(1):1-7

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