ZFIN Morpholino: MO1-dvl2

Target Location

Genome Build: GRCz11Chromosome: 7

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-dvl2

No data available

Phenotype

Phenotype resulting from MO1-dvl2

Phenotype	Fish	Figures
cardiac muscle cell orientation heart tube, abnormal	WT + MO1-dvl2	Fig. 3 from Merks et al., 2018
cardiac muscle cell establishment of animal organ orientation process quality, abnormal	WT + MO1-dvl2	Fig. 3 from Merks et al., 2018
cardiac muscle tissue morphogenesis process quality, abnormal	WT + MO1-dvl2	Fig. 2 from Merks et al., 2018
spinal cord duplicated, abnormal	WT + MO1-dvl2	Fig. S7 from Tawk et al., 2007

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Phenotype of all Fish created by or utilizing MO1-dvl2

Phenotype	Fish	Conditions	Figures
cardiac muscle cell orientation heart tube, abnormal	WT + MO1-dvl2	control	Fig. 3 from Merks et al., 2018
cardiac muscle cell establishment of animal organ orientation process quality, abnormal	WT + MO1-dvl2	control	Fig. 3 from Merks et al., 2018
spinal cord duplicated, abnormal	WT + MO1-dvl2	standard conditions	Fig. S7 from Tawk et al., 2007
cardiac muscle tissue morphogenesis process quality, abnormal	WT + MO1-dvl2	control	Fig. 2 from Merks et al., 2018
post-anal tail morphogenesis having extra processual parts post-anal tail morphogenesis, abnormal	WT + MO1-dvl2 + MO1-dvl3a	standard conditions	Fig. 3 from Yang et al., 2011

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Citations

Include unpublished citations

Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
Shimizu, N., Ishitani, S., Sato, A., Shibuya, H., Ishitani, T. (2014) Hipk2 and PP1c Cooperate to Maintain Dvl Protein Levels Required for Wnt Signal Transduction. Cell Reports. 8(5):1391-404
Mahuzier, A., Gaudé, H.M., Grampa, V., Anselme, I., Silbermann, F., Leroux-Berger, M., Delacour, D., Ezan, J., Montcouquiol, M., Saunier, S., Schneider-Maunoury, S., and Vesque, C. (2012) Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity. The Journal of cell biology. 198(5):927-940
Lum, W.M., Robertson, J.K., and Van Raay, T.J. (2011) Dishevelled2 is a stable protein during early zebrafish development. Zebrafish. 8(2):65-71
Yang, Y., and Thorpe, C. (2011) BMP and non-canonical Wnt signaling are required for inhibition of secondary tail formation in zebrafish. Development (Cambridge, England). 138(12):2601-2611
Zigman, M., Trinh, L.A., Fraser, S.E., and Moens, C.B. (2011) Zebrafish Neural Tube Morphogenesis Requires Scribble-Dependent Oriented Cell Divisions. Current biology : CB. 21(1):79-86
Segalen, M., Johnston, C.A., Martin, C.A., Dumortier, J.G., Prehoda, K.E., David, N.B., Doe, C.Q., and Bellaiche, Y. (2010) The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish. Developmental Cell. 19(5):740-752
Carreira-Barbosa, F., Kajita, M., Morel, V., Wada, H., Okamoto, H., Martinez Arias, A., Fujita, Y., Wilson, S.W., and Tada, M. (2009) Flamingo regulates epiboly and convergence/extension movements through cell cohesive and signalling functions during zebrafish gastrulation. Development (Cambridge, England). 136(3):383-392
Tawk, M., Araya, C., Lyons, D.A., Reugels, A.M., Girdler, G.C., Bayley, P.R., Hyde, D.R., Tada, M., and Clarke, J.D. (2007) A mirror-symmetric cell division that orchestrates neuroepithelial morphogenesis. Nature. 446(7137):797-800
Angers, S., Thorpe, C.J., Biechele, T.L., Goldenberg, S.J., Zheng, N., Maccoss, M.J., and Moon, R.T. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nature cell biology. 8(4):348-357

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