ZFIN is now using GRCz12tu for Genomic Data
Gene
dvl2
- ID
- ZDB-GENE-041118-20
- Name
- dishevelled segment polarity protein 2
- Symbol
- dvl2 Nomenclature History
- Previous Names
-
- sb:eu471
- wu:fc05d12
- wu:fo71e09
- wu:fp54a02
- zgc:55372
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable frizzled binding activity. Involved in convergent extension; non-canonical Wnt signaling pathway; and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Acts upstream of or within cell migration in hindbrain; convergent extension involved in axis elongation; and post-anal tail morphogenesis. Located in cell cortex and spindle. Is expressed in liver and vertebral column. Orthologous to human DVL2 (dishevelled segment polarity protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la016032Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029293Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6076 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20904 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40866 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sdu15 | Allele with one deletion | Unknown | Unknown | TALEN |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-dvl2 | (2) | |
| CRISPR2-dvl2 | (2) | |
| CRISPR3-dvl2 | (2) | |
| CRISPR4-dvl2 | (2) | |
| MO1-dvl2 | N/A | (10) |
| MO2-dvl2 | N/A | Carvalho et al., 2014 |
| MO3-dvl2 | N/A | Cheng et al., 2017 |
| TALEN1-dvl2 | (2) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | DEP domain | Dishevelled C-terminal | Dishevelled family | Dishevelled protein domain | Dishevelled-related protein | DIX domain | DIX domain superfamily | PDZ domain | PDZ superfamily | Ubiquitin-like domain superfamily | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q803Q5 | InterPro | 747 |
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Interactions and Pathways
No data available
Plasmids
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-335L21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-33C9 | ZFIN Curated Data | |
| Encodes | EST | eu471 | Thisse et al., 2005 | |
| Encodes | EST | fc05d12 | ZFIN Curated Data | |
| Encodes | EST | fp54a02 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55372 | ZFIN Curated Data | |
| Has Artifact | EST | fo71e09 | ZFIN Curated Data |
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| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_212648 (1) | 2604 nt | ||
| Genomic | GenBank:CR376787 (1) | 217684 nt | ||
| Polypeptide | UniProtKB:Q803Q5 (1) | 747 aa |
- Zhang, C., Wei, W., Lu, T., Zhang, Y., Li, J., Wang, J., Chen, A., Wen, F., Shao, M. (2024) Generation of Zebrafish Maternal Mutants via Oocyte-Specific Knockout System. Bio-protocol. 14:e5092e5092
- Zhang, C., Li, J., Tarique, I., Zhang, Y., Lu, T., Wang, J., Chen, A., Wen, F., Zhang, Z., Zhang, Y., Shao, M. (2021) A Time-Saving Strategy to Generate Double Maternal Mutants by an Oocyte-Specific Conditional Knockout System in Zebrafish. Biology. 10(8)
- Costa, R., Bellesso, S., Lualdi, S., Manzoli, R., Pistorio, V., Filocamo, M., Moro, E. (2020) A transcriptional and post-transcriptional dysregulation of Dishevelled 1 and 2 underlies the Wnt signaling impairment in type I Gaucher disease experimental models. Human molecular genetics. 29:285
- Menon, T., Borbora, A.S., Kumar, R., Nair, S. (2020) Dynamic optima in cell sizes during early development enable normal gastrulation in zebrafish embryos. Developmental Biology. 468(1-2):26-40
- Williams, M.L.K., Solnica-Krezel, L. (2020) Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. eLIFE. 9:
- Xiong, H., Huang, Y., Mao, Y., Liu, C., Wang, J. (2020) Inhibition in growth and cardiotoxicity of tris (2-butoxyethyl) phosphate through down-regulating Wnt signaling pathway in early developmental stage of zebrafish (Danio rerio). Ecotoxicology and environmental safety. 208:111431
- Čapek, D., Smutny, M., Tichy, A.M., Morri, M., Janovjak, H., Heisenberg, C.P. (2019) Light-activated Frizzled7 reveals a permissive role of non-canonical Wnt signaling in mesendoderm cell migration. eLIFE. 8:
- Cheung, C.T., Nguyen, T.V., Le Cam, A., Patinote, A., Journot, L., Reynes, C., Bobe, J. (2019) What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. BMC Genomics. 20:584
- Sun, X., Zhang, R., Liu, M., Chen, H., Chen, L., Luo, F., Zhang, D., Huang, J., Li, F., Ni, Z., Qi, H., Su, N., Jin, M., Yang, J., Tan, Q., Du, X., Chen, B., Huang, H., Chen, S., Yin, L., Xu, X., Deng, C., Luo, L., Xie, Y., Chen, L. (2019) Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage-hair hypoplasia via enhanced Wnt/β-catenin signaling. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 34(11):2101-2116
- Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
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