ZFIN Morpholino: MO1-gna12a

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-gna12a

No data available

Phenotype

Phenotype resulting from MO1-gna12a

No data available

Phenotype of all Fish created by or utilizing MO1-gna12a

Phenotype	Fish	Conditions	Figures
heart duplicated, abnormal	WT + MO1-gna12a + MO1-gna13a + MO1-gna13b	standard conditions	Fig. S1 from Ye et al., 2013
myelination of posterior lateral line nerve axons disrupted, abnormal	WT + MO1-gna12a + MO1-gna13a + MO1-gna13b	standard conditions	Fig. 3 from Ackerman et al., 2018
epiboly involved in gastrulation with mouth forming second disrupted, abnormal	WT + MO1-gna12a + MO1-gna13a + MO1-gna13b	standard conditions	Fig. 1, Fig. 6 from Lin et al., 2009
myelination of posterior lateral line nerve axons disrupted, abnormal	adgrg1^stl13/+ + MO1-gna12a + MO1-gna13a + MO1-gna13b	standard conditions	Fig. 3 from Ackerman et al., 2018
spinal cord oligodendrocyte development decreased occurrence, abnormal	adgrg1^stl13/+ + MO1-gna12a + MO1-gna13a + MO1-gna13b (AB)	standard conditions	Fig. 7 from Ackerman et al., 2015

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Citations

Include unpublished citations

Ackerman, S.D., Luo, R., Poitelon, Y., Mogha, A., Harty, B.L., D'Rozario, M., Sanchez, N.E., Lakkaraju, A.K.K., Gamble, P., Li, J., Qu, J., MacEwan, M.R., Ray, W.Z., Aguzzi, A., Feltri, M.L., Piao, X., Monk, K.R. (2018) GPR56/ADGRG1 regulates development and maintenance of peripheral myelin. The Journal of experimental medicine. 215(3):941-961
Ackerman, S.D., Garcia, C., Piao, X., Gutmann, D.H., Monk, K.R. (2015) The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA. Nature communications. 6:6122
Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2015) Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 523:468-71
Ye, D., and Lin, F. (2013) S1pr2/Gα₁₃ signaling controls myocardial migration by regulating endoderm convergence. Development (Cambridge, England). 140(4):789-799
Lin, F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E., and Solnica-Krezel, L. (2009) Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. The Journal of cell biology. 184(6):909-921
Lin, F., Sepich, D.S., Chen, S., Topczewski, J., Yin, C., Solnica-Krezel, L., and Hamm, H. (2005) Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. The Journal of cell biology. 169(5):777-787

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