ZFIN Morpholino: MO2-nrp1a

Target Location

Genome Build: GRCz11Chromosome: 24

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-nrp1a

No data available

Phenotype

Phenotype resulting from MO2-nrp1a

Phenotype	Fish	Figures
anterior commissure axon decreased distribution, abnormal	RW + MO2-nrp1a	Fig. 6 from Guo et al., 2022
anterior commissure axon ab1-tuba labeling spatial pattern, abnormal	RW + MO2-nrp1a	Fig. 6 from Guo et al., 2022
axon extension process quality, abnormal	WT + MO2-nrp1a	Fig. 9 from Chitramuthu et al., 2010
axon guidance disrupted, abnormal	AB + MO2-nrp1a	Fig. 3 from Kuan et al., 2007
brain hemorrhagic, abnormal	WT + MO2-nrp1a + MO4-tp53	Fig. 4 from Hirota et al., 2015

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Phenotype of all Fish created by or utilizing MO2-nrp1a

Phenotype	Fish	Conditions	Figures
habenula axon misrouted, abnormal	AB + MO2-nrp1a	standard conditions	Fig. 3 from Kuan et al., 2007
axon guidance disrupted, abnormal	AB + MO2-nrp1a	standard conditions	Fig. 3 from Kuan et al., 2007
CaP motoneuron axon decreased length, abnormal	AB + MO2-nrp1a	standard conditions	text only from Cantu et al., 2013
interpeduncular nucleus tegmentum structure, abnormal	AB + MO2-nrp1a	standard conditions	Fig. 3 from Kuan et al., 2007
postoptic commissure axon ab1-tuba labeling spatial pattern, abnormal	RW + MO2-nrp1a	control	Fig. 6 from Guo et al., 2022

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Citations

Include unpublished citations

Liu, Z.Z., Liu, L.Y., Zhu, L.Y., Zhu, J., Luo, J.Y., Wang, Y.F., Xu, H.A. (2024) Plexin B3 guides axons to cross the midline in vivo. Frontiers in Cellular Neuroscience. 18:12929691292969
Guo, Y., Oliveros, C.F., Ohshima, T. (2022) CRMP2 and CRMP4 are required for the formation of commissural tracts in the developing zebrafish forebrain. Developmental Neurobiology. 82(6):533-544
Liu, Z.Z., Zhu, J., Wang, C.L., Wang, X., Han, Y.Y., Liu, L.Y., Xu, H.A. (2018) CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons. Neural Plasticity. 2018:8791304
Hamm, M.J., Kirchmaier, B.C., Herzog, W. (2016) Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1. The Journal of cell biology. 215(3):415-430
Hörnberg, H., Cioni, J.M., Harris, W.A., Holt, C.E. (2016) Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:12697-12706
Balastik, M., Zhou, X. Z., Alberich-Jorda, M., Weissova, R., Žiak, J., Pazyra-Murphy, M. F., Cosker, K. E., Machonova, O., Kozmikova, I., Chen, C. H., Pastorino, L., Asara, J. M., Cole, A., Sutherland, C., Segal, R. A., Lu, K.P. (2015) Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.. Cell Reports. 13(4):812-28
Delcourt, N., Quevedo, C., Nonne, C., Fons, P., O'Brien, D., Loyaux, D., Diez, M., Autelitano, F., Guillemot, J.C., Ferrara, P., Muriana, A., Callol, C., Hérault, J.P., Herbert, J.M., Favre, G., Bono, F. (2015) Targeted Identification of Sialoglycoproteins in Hypoxic Endothelial Cells and Validation in Zebrafish Reveal Roles for Proteins in Angiogenesis. The Journal of biological chemistry. 290(6):3405-17
Fantin, A., Lampropoulou, A., Gestri, G., Raimondi, C., Senatore, V., Zachary, I., Ruhrberg, C. (2015) NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Reports. 11(10):1577-90
Hirota, S., Clements, T.P., Tang, L.K., Morales, J.E., Lee, H.S., Oh, S.P., Rivera, G.M., Wagner, D.S., McCarty, J.H. (2015) Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Development (Cambridge, England). 142:4363-73
Cantu, J.A., Flowers, G.P., and Topczewski, J. (2013) Notum homolog plays a novel role in primary motor innervation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(5):2177-2187

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