ZFIN Morpholino: MO2-bmp2b

Target Location

Genome Build: GRCz11Chromosome: 20

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-bmp2b

No data available

Phenotype

Phenotype resulting from MO2-bmp2b

Phenotype	Fish	Figures
caudal fin shortened, abnormal	WT + MO2-bmp2b	Fig. 3 from Gan et al., 2016
ceratobranchial cartilage absent, abnormal	WT + MO2-bmp2b	Fig. 5 from Gan et al., 2016
Meckel's cartilage decreased size, abnormal	WT + MO2-bmp2b	Fig. 5 from Gan et al., 2016
neuroectoderm wholly dorsalized, abnormal	WT + MO2-bmp2b	Fig. 3 from Sun et al., 2014
trunk curved, abnormal	WT + MO2-bmp2b	Fig. 3 from Gan et al., 2016

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Phenotype of all Fish created by or utilizing MO2-bmp2b

Phenotype	Fish	Conditions	Figures
whole organism morphology, abnormal	WT + MO2-bmp2b	standard conditions	Fig. 3 from Gan et al., 2016
caudal fin shortened, abnormal	WT + MO2-bmp2b	standard conditions	Fig. 3 from Gan et al., 2016
whole organism ab1-bmp2b labeling decreased amount, abnormal	WT + MO2-bmp2b	standard conditions	Fig. 3 from Gan et al., 2016
Meckel's cartilage decreased size, abnormal	WT + MO2-bmp2b	standard conditions	Fig. 5 from Gan et al., 2016
ceratobranchial cartilage absent, abnormal	WT + MO2-bmp2b	standard conditions	Fig. 5 from Gan et al., 2016

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Citations

Include unpublished citations

Zinski, J., Bu, Y., Wang, X., Dou, W., Umulis, D., Mullins, M. (2017) Systems biology derived source-sink mechanism of BMP gradient formation. eLIFE. 6
Gan, S., Huang, Z., Liu, N., Su, R., Xie, G., Zhong, B., Zhang, K., Wang, S., Hu, X., Zhang, J., Xiang, S. (2016) MicroRNA-140-5p impairs zebrafish embryonic bone development via targeting BMP-2. FEBS letters. 590(10):1438-46
Holtzhausen, A., Golzio, C., How, T., Lee, Y.H., Schiemann, W.P., Katsanis, N., and Blobe, G.C. (2014) Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 28(3):1248-67
Sun, Y., Tseng, W.C., Fan, X., Ball, R., and Dougan, S.T. (2014) Extraembryonic signals under the control of MGA, Max, and Smad4 are required for dorsoventral patterning. Developmental Cell. 28(3):322-334
Xue, Y., Zheng, X., Huang, L., Xu, P., Ma, Y., Min, Z., Tao, Q., Tao, Y., Meng, A. (2014) Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development. Nature communications. 5:3766
Ramel, M.C., and Hill, C.S. (2013) The ventral to dorsal BMP activity gradient in the early zebrafish embryo is determined by graded expression of BMP ligands. Developmental Biology. 378(2):170-82
Varga, M., Maegawa, S., and Weinberg, E.S. (2011) Correct anteroposterior patterning of the zebrafish neurectoderm in the absence of the early dorsal organizer. BMC Developmental Biology. 11(1):26
Little, S.C., and Mullins, M.C. (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nature cell biology. 11(5):637-643
Chung, W.S., Shin, C.H., and Stainier, D.Y. (2008) Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Developmental Cell. 15(5):738-748
Varga, M., Maegawa, S., Bellipanni, G., and Weinberg, E.S. (2007) Chordin expression, mediated by Nodal and FGF signaling, is restricted by redundant function of two beta-catenins in the zebrafish embryo. Mechanisms of Development. 124(9-10):775-791

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