ZFIN ID: ZDB-PUB-010917-4
Morpholino phenocopies of the bmp2b/swirl and bmp7/snailhouse mutations
Imai,Y. and Talbot, W.S.
Date: 2001
Source: Genesis (New York, N.Y. : 2000)   30(3): 160-163 (Journal)
Registered Authors: Imai, Yoshiyuki, Talbot, William S.
Keywords: bmp; zebrafish; dorsoventral pattern formation; genes
MeSH Terms:
  • Animals
  • Bone Morphogenetic Protein 2
  • Bone Morphogenetic Protein 7
  • Bone Morphogenetic Proteins/genetics*
  • Bone Morphogenetic Proteins/metabolism
  • Gene Expression Regulation, Developmental
  • Oligonucleotides, Antisense/genetics*
  • Phenotype
  • Point Mutation/genetics*
  • Transforming Growth Factor beta*
  • Zebrafish/embryology*
  • Zebrafish/genetics*
  • Zebrafish Proteins/genetics
PubMed: 11477698 Full text @ Genesis
Bone morphogenetic proteins (BMPs), members of the TGF-beta superfamily, are essential for dorsoventral patterning in the early embryo. In zebrafish, mutations in the bmp2b/swirl and bmp7/snailhouse genes produce dorsalized embryos in which paraxial mesoderm and the neural plate are expanded at the expense of ventral structures, demonstrating that bmp2b/swirl and bmp7/snailhouse are required for specification of ventral cell fates (Dick et al., 2000; Kishimoto et al., 1997; Mullins et al., 1996; Nguyen et al., 1998; Schmid et al., 2000). Here, we report phenotypes of bmp2b/swirl and bmp7/snailhouse mutations produced by antisense morpholino oligonucleotide injection.